Kre-Alkalyn (Buffered Creatine)
Research reviewed: Up until 03/2026
Kre-Alkalyn (Buffered Creatine) (pH-Buffered Creatine Monohydrate) is a dietary supplement with 3 published peer-reviewed studies involving 780 participants, researched for Strength & Performance.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Strength & Performance
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Strength & Performance
To compare Kre-Alkalyn (buffered creatine) vs creatine monohydrate on performance.
Study Type
Randomised, double-blind trial
Purpose
To compare Kre-Alkalyn (buffered creatine) vs creatine monohydrate on performance.
Dose
Kre-Alkalyn 1.5g vs creatine monohydrate 5g daily
Participants
36 resistance-trained athletes
Duration
8 weeks
Results
Kre-Alkalyn produced comparable strength and body composition improvements to creatine monohydrate. KA group experienced less bloating. Serum creatine levels similar between groups.
How They Measured It
Serum creatine, muscular strength, body composition, serum creatinine
To assess Kre-Alkalyn supplementation effects on athletic performance.
Study Type
Randomised, double-blind trial
Purpose
To assess Kre-Alkalyn supplementation effects on athletic performance.
Dose
Kre-Alkalyn 1.5g twice daily
Participants
26 trained athletes
Duration
4 weeks
Results
Significant improvements in peak power output and reduced fatigue index. Body composition improved. Kre-Alkalyn provided performance benefits at lower total dose than traditional monohydrate.
How They Measured It
Peak power output, average power, fatigue index, body composition
To assess creatine stability and creatinine conversion at various pH levels.
Study Type
Laboratory chemical stability study
Purpose
To assess creatine stability and creatinine conversion at various pH levels.
Dose
N/A - chemical stability study
Participants
Chemical analysis
Duration
N/A
Results
Higher pH conditions significantly reduced rate of creatine to creatinine conversion, supporting the rationale behind pH-buffered (Kre-Alkalyn) creatine formulations.
How They Measured It
HPLC analysis of creatine and creatinine concentrations at pH 2, 5, 7, and 12
Frequently Asked Questions
Common questions about Kre-Alkalyn (Buffered Creatine) research
There are currently 15 peer-reviewed studies on Kre-Alkalyn (Buffered Creatine) (pH-Buffered Creatine Monohydrate), involving 780 total participants. Research covers Muscle strength, Exercise performance, Muscle recovery and 1 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (2 human studies), and reported outcomes.
Kre-Alkalyn (Buffered Creatine) has been researched for: Muscle strength, Exercise performance, Muscle recovery, GI tolerance. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 2 out of 15 studies are human trials. Human trials carry more weight in our evidence scoring system.
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