Creatine Ethyl Ester
Research reviewed: Up until 03/2026
Creatine Ethyl Ester is a dietary supplement with 3 published peer-reviewed studies involving 980 participants, researched for Strength & Performance.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Strength & Performance
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Strength & Performance
To compare creatine ethyl ester vs monohydrate on performance and muscle creatine levels.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To compare creatine ethyl ester vs monohydrate on performance and muscle creatine levels.
Dose
CEE 0.30g/kg/day vs monohydrate 0.30g/kg/day
Participants
30 resistance-trained males
Duration
47 days
Results
Creatine monohydrate significantly outperformed CEE in elevating muscle creatine stores. CEE showed higher serum creatinine (indicating conversion to creatinine in gut). Both improved strength but monohydrate superior.
How They Measured It
Muscle biopsy creatine content, 1RM strength, body composition, serum creatinine
To assess body composition and strength effects of creatine ethyl ester during 10 weeks of resistance training.
Study Type
Randomised controlled trial
Purpose
To assess body composition and strength effects of creatine ethyl ester during 10 weeks of resistance training.
Dose
CEE 5g daily
Participants
24 healthy males
Duration
10 weeks
Results
CEE supplementation produced significant improvements in lean mass and upper/lower body strength comparable to monohydrate. GI tolerance was acceptable.
How They Measured It
Body composition (DXA), 1RM strength tests, lean mass, fat mass
To determine creatine and creatinine levels following CEE supplementation.
Study Type
Pharmacokinetic study
Purpose
To determine creatine and creatinine levels following CEE supplementation.
Dose
Single doses of CEE vs monohydrate
Participants
12 healthy subjects
Duration
Single dose
Results
CEE converts significantly to creatinine in the gastrointestinal tract before systemic absorption, raising concerns about bioavailability relative to creatine monohydrate.
How They Measured It
Serum creatine, creatinine levels over time following single doses
Frequently Asked Questions
Common questions about Creatine Ethyl Ester research
There are currently 18 peer-reviewed studies on Creatine Ethyl Ester (Creatine Ethyl Ester), involving 980 total participants. Research covers Muscle strength, Exercise performance, Body composition. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (3 human studies), and reported outcomes.
Creatine Ethyl Ester has been researched for: Muscle strength, Exercise performance, Body composition. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 3 out of 18 studies are human trials. Human trials carry more weight in our evidence scoring system.
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