Spleen Extract
Research reviewed: 1985–2016
Spleen Extract (Bovine spleen extract) is a dietary supplement with 8 published peer-reviewed studies involving 486 participants, researched for Immune Function, White Blood Cell Support, Infection Resistance and 1 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Immune Function
ModerateWhite Blood Cell Support
ModerateInfection Resistance
ModerateImmune Peptides & Mechanisms
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Immune Function
Evaluate bovine spleen extract on immune cell populations
Study Type
Randomised Controlled Trial
Purpose
Evaluate bovine spleen extract on immune cell populations
Dose
Spleen extract 100 mg/day
Participants
60
Duration
8 weeks
Results
Significant increase in total white blood cells; neutrophil phagocytic activity improved; NK cell cytotoxicity enhanced
How They Measured It
White blood cell counts, neutrophil function, NK cells
Assess spleen extract on immune function after surgery
Study Type
Randomised Controlled Trial
Purpose
Assess spleen extract on immune function after surgery
Dose
Spleen extract 200 mg/day
Participants
80
Duration
4 weeks
Results
Faster white blood cell recovery post-surgery; significantly fewer post-surgical infections; wound healing improved
How They Measured It
Post-surgical WBC recovery, infection frequency, wound healing
White Blood Cell Support
Evaluate spleen extract on leukocyte function in chemotherapy patients
Study Type
Randomised Controlled Trial
Purpose
Evaluate spleen extract on leukocyte function in chemotherapy patients
Dose
Spleen extract 300 mg/day
Participants
80
Duration
6 months
Results
Significantly better WBC maintenance during chemo; fewer dose reductions needed; infection rate reduced by 28%
How They Measured It
WBC counts, neutrophil count, infection rate
Assess spleen peptides as immunostimulants in elderly
Study Type
Randomised Controlled Trial
Purpose
Assess spleen peptides as immunostimulants in elderly
Dose
Spleen extract 100 mg/day
Participants
50
Duration
12 weeks
Results
Improved lymphocyte proliferative response; enhanced phagocytic capacity; cytokine production normalised in elderly subjects
How They Measured It
Lymphocyte proliferation, cytokine production, phagocytic activity
Infection Resistance
Evaluate spleen peptide tuftsin on infection resistance
Study Type
Randomised Controlled Trial
Purpose
Evaluate spleen peptide tuftsin on infection resistance
Dose
Tuftsin-containing spleen extract
Participants
75
Duration
6 months
Results
Tuftsin significantly activated macrophages; infection frequency reduced; neutrophil migration enhanced; well-tolerated
How They Measured It
Infection frequency, macrophage activation, neutrophil function
Assess spleen extract for recurrent infections in adults
Study Type
Randomised Controlled Trial
Purpose
Assess spleen extract for recurrent infections in adults
Dose
Spleen extract 200 mg/day
Participants
60
Duration
6 months
Results
Recurrent infection frequency reduced by 38%; antibiotic use reduced; immune markers improved; no adverse events
How They Measured It
Infection recurrence, duration, antibiotic use, immune markers
Immune Peptides & Mechanisms
Evaluate spleen extract on immunity and WBC counts in asplenic patients
Study Type
Randomised Controlled Trial
Purpose
Evaluate spleen extract on immunity and WBC counts in asplenic patients
Dose
Spleen extract 300 mg/day
Participants
40
Duration
12 weeks
Results
Partial immune compensation in asplenic patients; WBC counts improved; NK cell activity restored; protective effect
How They Measured It
WBC subsets, NK cells, antibody production
Assess tuftsin from spleen extract in clinical immune modulation
Study Type
Randomised Controlled Trial
Purpose
Assess tuftsin from spleen extract in clinical immune modulation
Dose
Tuftsin-enriched spleen extract 100 mg/day
Participants
41
Duration
8 weeks
Results
Significant improvement in monocyte chemotaxis; NK cell activity elevated; T-cell ratios normalised; mechanism via tuftsin receptors
How They Measured It
Monocyte chemotaxis, NK cell activity, T-cell subsets
Frequently Asked Questions
Common questions about Spleen Extract research
There are currently 8 peer-reviewed studies on Spleen Extract (Bovine spleen extract), involving 486 total participants. Research covers Immune Function, White Blood Cell Support, Infection Resistance and 1 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (8 human studies), and reported outcomes.
Spleen Extract has been researched for: Immune Function, White Blood Cell Support, Infection Resistance, Immune Peptides. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 8 out of 8 studies are human trials. Human trials carry more weight in our evidence scoring system.
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