Myricetin
Research reviewed: 2023-2025
Myricetin (Myricetin (3,5,7,3',4',5'-hexahydroxyflavone)) is a dietary supplement with 12 published peer-reviewed studies involving 387 participants, researched for Cancer Prevention, Diabetes & Metabolic Health, Neuroprotection & Antioxidant and 3 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Cancer Prevention
ModerateDiabetes & Metabolic Health
ModerateNeuroprotection & Antioxidant
WeakReviews & Mechanisms
WeakBlood Sugar
ModerateMood & Mental Health
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Cancer Prevention
To investigate dietary myricetin intake and prostate cancer risk.
Study Type
Prospective cohort
Purpose
To investigate dietary myricetin intake and prostate cancer risk.
Dose
Dietary myricetin intake (observational)
Participants
29,133 men in Health Professionals Follow-up Study
Duration
14 years follow-up
Results
Higher dietary myricetin intake associated with 22% lower prostate cancer risk; strongest protection for aggressive disease.
How They Measured It
FFQ dietary assessment; prostate cancer incidence from registry
To characterise myricetin's pro-apoptotic and anti-migratory effects in pancreatic cancer cells.
Study Type
In vitro mechanistic study
Purpose
To characterise myricetin's pro-apoptotic and anti-migratory effects in pancreatic cancer cells.
Dose
10-100 µM myricetin
Participants
PANC-1 and MIAPaCa-2 pancreatic cancer cells
Duration
24-72 hours
Results
Myricetin induced dose-dependent apoptosis via both extrinsic and intrinsic pathways; significantly inhibited cancer cell invasion and MMP-9 expression.
How They Measured It
Caspase cascade, PARP cleavage, Matrigel invasion assay, MMP-9 expression
To evaluate dietary myricetin intake and lung cancer risk.
Study Type
Case-control study
Purpose
To evaluate dietary myricetin intake and lung cancer risk.
Dose
Dietary intake (observational)
Participants
1390 lung cancer cases and controls
Duration
Case-control
Results
Highest tertile of myricetin intake associated with 28% lower lung cancer risk; significance strongest in never-smokers.
How They Measured It
FFQ; lung cancer case-control
Diabetes & Metabolic Health
To evaluate myricetin supplementation on insulin resistance and glycaemic control.
Study Type
RCT
Purpose
To evaluate myricetin supplementation on insulin resistance and glycaemic control.
Dose
50 mg myricetin daily
Participants
56 adults with type 2 diabetes
Duration
8 weeks
Results
Significant reductions in fasting glucose (-11%), HOMA-IR (-18%), and HbA1c (-0.5%) compared to placebo.
How They Measured It
Fasting glucose, HOMA-IR, HbA1c, fasting insulin
To investigate myricetin's mechanisms for improving insulin sensitivity and glucose uptake.
Study Type
In vitro and animal study
Purpose
To investigate myricetin's mechanisms for improving insulin sensitivity and glucose uptake.
Dose
5-25 µM myricetin in vitro; 50-200 mg/kg in rats
Participants
L6 muscle cells; streptozotocin-diabetic rats
Duration
48 hours / 4 weeks
Results
Myricetin promoted GLUT4 translocation via PI3K/Akt pathway and enhanced muscle glucose uptake; insulin sensitising effects confirmed in diabetic rat model.
How They Measured It
GLUT4 translocation, PI3K/Akt pathway activation, glucose uptake in muscle cells
Neuroprotection & Antioxidant
To assess myricetin's neuroprotective effects against beta-amyloid-induced toxicity.
Study Type
In vitro study
Purpose
To assess myricetin's neuroprotective effects against beta-amyloid-induced toxicity.
Dose
1-20 µM myricetin
Participants
Primary rat hippocampal neurons
Duration
48-hour Abeta exposure
Results
Myricetin significantly protected neurons from Abeta toxicity; reduced tau hyperphosphorylation via GSK-3beta inhibition; decreased neuronal ROS by 60%.
How They Measured It
Neuronal viability, ROS measurement, tau phosphorylation, GSK-3beta activity
To evaluate myricetin on cognitive function and oxidative stress in aged mice.
Study Type
Animal study
Purpose
To evaluate myricetin on cognitive function and oxidative stress in aged mice.
Dose
10-30 mg/kg myricetin orally
Participants
Aged D-galactose-induced aging mouse model
Duration
4 weeks
Results
Myricetin significantly improved spatial memory and passive avoidance; reduced brain oxidative stress markers; enhanced brain antioxidant enzyme activities.
How They Measured It
Morris water maze, passive avoidance test, brain MDA, SOD
Reviews & Mechanisms
To pool evidence on flavonoid intake (including myricetin) and cancer risk reduction.
Study Type
Meta-analysis
Purpose
To pool evidence on flavonoid intake (including myricetin) and cancer risk reduction.
Dose
Dietary flavonoid exposure
Participants
Multiple studies pooled
Duration
Review
Results
Myricetin exhibited the strongest inverse association with prostate cancer in pooled analysis; also protective for lung and colorectal cancer.
How They Measured It
Pooled RR from prospective cohorts and case-controls
To review myricetin's full spectrum of pharmacological activities.
Study Type
Systematic review
Purpose
To review myricetin's full spectrum of pharmacological activities.
Dose
Varied
Participants
Multiple studies reviewed
Duration
Review
Results
Myricetin exhibits potent antioxidant, anti-diabetic, anti-cancer, and neuroprotective properties; bioavailability limitations require formulation strategies for clinical application.
How They Measured It
Comprehensive literature synthesis
Blood Sugar
Imera cultivar carob: clinical glycemic effects and phytochemical profile.
Study Type
RCT
Purpose
Imera cultivar carob: clinical glycemic effects and phytochemical profile.
Dose
See study
Participants
15 participants
Duration
1 months
Results
significantly lowered glucose levels (109.
How They Measured It
PubMed PMID: 41166808. Food Chem
Mood & Mental Health
Consumption of Sylimarin, Pyrroloquinoline Quinone Sodium Salt and Myricetin: Effects on Alcohol Levels and Markers of Oxidative Stress-A Pilot Study.
Study Type
RCT
Purpose
Consumption of Sylimarin, Pyrroloquinoline Quinone Sodium Salt and Myricetin: Effects on Alcohol Levels and Markers of Oxidative Stress-A Pilot Study.
Dose
See study
Participants
Not specified
Duration
1 weeks
Results
CONCLUSION: After the administration of Si.
How They Measured It
PubMed PMID: 39275279. Nutrients
[Efficacy, safety, and mechanism of Huangkui Capsules in treating chronic kidney disease: Meta-analysis and integrative bioinformatics].
Study Type
Meta-Analysis
Purpose
[Efficacy, safety, and mechanism of Huangkui Capsules in treating chronic kidney disease: Meta-analysis and integrative bioinformatics].
Dose
See study
Participants
372 participants
Duration
24 weeks
Results
significantly reduced urine protein, Scr, and BUN.
How They Measured It
PubMed PMID: 37802876. Zhongguo Zhong Yao Za Zhi
Frequently Asked Questions
Common questions about Myricetin research
There are currently 12 peer-reviewed studies on Myricetin (Myricetin (3,5,7,3',4',5'-hexahydroxyflavone)), involving 387 total participants. Research covers Cancer prevention, Diabetes management, Neuroprotection and 1 more areas. The overall evidence strength is rated as Moderate.
The evidence is currently rated as "Moderate Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (6 human studies), and reported outcomes.
Myricetin has been researched for: Cancer prevention, Diabetes management, Neuroprotection, Antioxidant protection. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 6 out of 12 studies are human trials. Human trials carry more weight in our evidence scoring system.
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