Hydroxytyrosol
Research reviewed: Up until 03/2026
Hydroxytyrosol (Hydroxytyrosol (3,4-dihydroxyphenylethanol)) is a dietary supplement with 2 published peer-reviewed studies involving 2,100 participants, researched for Cardiovascular & Antioxidant.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Cardiovascular & Antioxidant
StrongResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Cardiovascular & Antioxidant
To assess hydroxytyrosol on LDL oxidation and cardiovascular risk.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To assess hydroxytyrosol on LDL oxidation and cardiovascular risk.
Dose
Hydroxytyrosol 5mg/day as olive polyphenol extract
Participants
55 healthy adults
Duration
8 weeks
Results
Significant reduction in oxidised LDL and 8-isoprostane (oxidative stress marker). Improved total antioxidant capacity. EFSA-approved health claim for LDL oxidation protection supported.
How They Measured It
Oxidised LDL, 8-isoprostane, total antioxidant capacity, blood pressure
To evaluate olive polyphenol extract (high hydroxytyrosol) on blood pressure.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate olive polyphenol extract (high hydroxytyrosol) on blood pressure.
Dose
Olive polyphenol extract providing 9.7mg HT daily
Participants
40 stage 1 hypertensive adults
Duration
12 weeks
Results
Significant reduction in systolic blood pressure (-6.9 mmHg) and improvement in endothelial function. Arterial stiffness indices improved. Hydroxytyrosol identified as key vasoactive component.
How They Measured It
Systolic and diastolic blood pressure, endothelial function (FMD), arterial stiffness
Frequently Asked Questions
Common questions about Hydroxytyrosol research
There are currently 42 peer-reviewed studies on Hydroxytyrosol (Hydroxytyrosol (3,4-dihydroxyphenylethanol)), involving 2,100 total participants. Research covers Cardiovascular health, Antioxidant protection, Anti-inflammatory and 1 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (2 human studies), and reported outcomes.
Hydroxytyrosol has been researched for: Cardiovascular health, Antioxidant protection, Anti-inflammatory, Neuroprotection. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 2 out of 42 studies are human trials. Human trials carry more weight in our evidence scoring system.
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