Oleuropein
Research reviewed: 2025-2026
Oleuropein (Oleuropein (Olea europaea leaf compound)) is a dietary supplement with 7 published peer-reviewed studies involving 1,391 participants, researched for Cardiovascular & Antioxidant, Heart Health.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Cardiovascular & Antioxidant
StrongHeart Health
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Cardiovascular & Antioxidant
To assess olive leaf extract (standardised to oleuropein) on blood pressure.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To assess olive leaf extract (standardised to oleuropein) on blood pressure.
Dose
Olive leaf extract 500mg (containing 100mg oleuropein) twice daily
Participants
60 stage 1 hypertensive adults
Duration
8 weeks
Results
Olive leaf extract significantly reduced systolic BP by 11.5 mmHg and diastolic by 4.8 mmHg vs placebo. LDL cholesterol also reduced. Comparable to captopril 25mg twice daily.
How They Measured It
Systolic and diastolic blood pressure, heart rate, lipid profile
To evaluate olive leaf extract effect on insulin sensitivity in overweight adults.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate olive leaf extract effect on insulin sensitivity in overweight adults.
Dose
Olive leaf extract 51.1mg oleuropein daily
Participants
46 overweight middle-aged men
Duration
12 weeks
Results
Olive leaf extract significantly improved insulin sensitivity (by 15%) and pancreatic beta-cell responsiveness. Oleuropein may prevent type 2 diabetes development.
How They Measured It
Insulin secretion, insulin sensitivity, glucose metabolism (clamp technique)
Heart Health
The impact of olive oil polyphenol supplementation on metabolic syndrome parameters The OleoMetS study: A randomized, controlled clinical trial.
Study Type
RCT
Purpose
The impact of olive oil polyphenol supplementation on metabolic syndrome parameters The OleoMetS study: A randomized, controlled clinical trial.
Dose
See study
Participants
110 participants
Duration
12 weeks
Results
CONCLUSION: Supplementation with OOPs shows promise in improving key metabolic markers in patients with MetS.
How They Measured It
PubMed PMID: 41429309. Clin Nutr ESPEN
Effects of olive leaf extract supplementation on systemic markers of tissue aging and remodeling in postmenopausal women: a randomized controlled tria
Study Type
RCT
Purpose
Effects of olive leaf extract supplementation on systemic markers of tissue aging and remodeling in postmenopausal women: a randomized controlled tria
Dose
See study
Participants
26 participants
Duration
12 weeks
Results
CONCLUSION: The exploratory skin analyses revealed a reduction in pore number and surface skewness, suggesting that OLE may exert localized effects on skin structure.
How They Measured It
PubMed PMID: 41340653. Front Nutr
Efficacy of olive leaf extracts in controlling blood pressure in hypertensive patients: a double-blind randomized clinical trial.
Study Type
RCT
Purpose
Efficacy of olive leaf extracts in controlling blood pressure in hypertensive patients: a double-blind randomized clinical trial.
Dose
See study
Participants
621 participants
Duration
12 weeks
Results
CONCLUSION: OLE can decrease 24-h BP, BPL, and diastolic BPV with improvement of lipid profile, systemic inflammation, and body weight in hypertensive patients.
How They Measured It
PubMed PMID: 40990594. J Hypertens
Oleuropein Supplementation Increases Resting Skeletal Muscle Fractional Pyruvate Dehydrogenase Activity but Does Not Influence Whole-Body Metabolism:
Study Type
RCT
Purpose
Oleuropein Supplementation Increases Resting Skeletal Muscle Fractional Pyruvate Dehydrogenase Activity but Does Not Influence Whole-Body Metabolism:
Dose
See study
Participants
40 participants
Duration
Not specified
Results
CONCLUSIONS: Chronic OLE supplementation resulted in higher skeletal muscle fractional PDH activity in healthy, older males, which may impact resting energy metabolism.
How They Measured It
PubMed PMID: 39993475. J Nutr
The impact of oleuropein, hydroxytyrosol, and tyrosol on cardiometabolic risk factors: a meta-analysis of randomized controlled trials.
Study Type
Meta-Analysis
Purpose
The impact of oleuropein, hydroxytyrosol, and tyrosol on cardiometabolic risk factors: a meta-analysis of randomized controlled trials.
Dose
See study
Participants
594 participants
Duration
Not specified
Results
significantly reduced total cholesterol (SMD = -0.
How They Measured It
PubMed PMID: 39828996. Crit Rev Food Sci Nutr
Frequently Asked Questions
Common questions about Oleuropein research
There are currently 7 peer-reviewed studies on Oleuropein (Oleuropein (Olea europaea leaf compound)), involving 1,391 total participants. Research covers Cardiovascular health, Antioxidant protection, Anti-inflammatory and 1 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (7 human studies), and reported outcomes.
Oleuropein has been researched for: Cardiovascular health, Antioxidant protection, Anti-inflammatory, Antiviral. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 7 out of 7 studies are human trials. Human trials carry more weight in our evidence scoring system.
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