Gamma Oryzanol
Research reviewed: Up until 03/2026
Gamma Oryzanol (Gamma-Oryzanol (γ-Oryzanol)) is a dietary supplement with 9 published peer-reviewed studies involving 450 participants, researched for Cholesterol & Lipid Management, Sports Performance & Muscle Strength, Menopausal Symptoms and 2 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Cholesterol & Lipid Management
WeakSports Performance & Muscle Strength
WeakMenopausal Symptoms
ModerateMetabolic Health & Diabetes
StrongHormonal & Endocrine Effects
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Cholesterol & Lipid Management
To evaluate the effects of rice bran oil containing different concentrations of gamma-oryzanol on lipid profiles and antioxidant status in hyperlipidemic subjects.
Study Type
Randomized, double-blind, controlled trial
Purpose
To evaluate the effects of rice bran oil containing different concentrations of gamma-oryzanol on lipid profiles and antioxidant status in hyperlipidemic subjects.
Dose
30 mL/day rice bran oil with 4,000, 8,000, or 11,000 ppm gamma-oryzanol vs soybean oil control
Participants
59 hyperlipidemic subjects (four groups, 14-15 per group)
Duration
4 weeks
Results
LDL cholesterol decreased significantly with rice bran oil (11.8-12.2% reduction in highest gamma-oryzanol groups vs 0.8% in controls). Antioxidant capacity improved: ORAC up to 10.1%, FRAP up to 7.6% in treatment groups.
How They Measured It
LDL cholesterol, total cholesterol, antioxidant capacity (ORAC, FRAP), inflammatory markers
To compare cholesterol-lowering properties of rice bran oil with varied gamma-oryzanol content in mildly hypercholesterolemic men.
Study Type
Randomized controlled trial
Purpose
To compare cholesterol-lowering properties of rice bran oil with varied gamma-oryzanol content in mildly hypercholesterolemic men.
Dose
50 g/day rice bran oil with low (0.05 g/day) or high (0.8 g/day) gamma-oryzanol
Participants
30 mildly hypercholesterolemic men, ages 38-64
Duration
4 weeks (after 2-week run-in)
Results
Both formulations produced comparable improvements: total cholesterol decreased 6.3%, LDL cholesterol 10.5%, LDL/HDL ratio 18.9%. Gamma-oryzanol content differences had no significant impact on cholesterol-lowering effectiveness.
How They Measured It
Total cholesterol, LDL cholesterol, HDL cholesterol, LDL/HDL ratio
To evaluate the effects of gamma-oryzanol on serum lipids and apolipoproteins in dyslipidemic patients receiving major tranquilizers.
Study Type
Clinical intervention study
Purpose
To evaluate the effects of gamma-oryzanol on serum lipids and apolipoproteins in dyslipidemic patients receiving major tranquilizers.
Dose
100 mg gamma-oryzanol three times daily (300 mg/day)
Participants
20 chronic schizophrenic patients with dyslipidemia
Duration
16 weeks
Results
Total cholesterol decreased from 204 to 176 mg/dL by week 12. LDL cholesterol decreased from 124 to 101 mg/dL. Apo B decreased from 116 to 101 mg/dL. Apo B/Apo A-I ratio declined from 0.99 to 0.84. No treatment side effects recorded.
How They Measured It
Total cholesterol, LDL cholesterol, apolipoproteins A-I, A-II, and B levels
Sports Performance & Muscle Strength
To evaluate the effects of gamma-oryzanol supplementation on anthropometric measurements and muscular strength during resistance training.
Study Type
Randomized, double-blind, placebo-controlled trial
Purpose
To evaluate the effects of gamma-oryzanol supplementation on anthropometric measurements and muscular strength during resistance training.
Dose
600 mg/day gamma-oryzanol
Participants
30 healthy male volunteers (16 supplement, 14 placebo)
Duration
9 weeks
Results
No significant effects on body measurements or skin fold thickness. However, gamma-oryzanol demonstrated significant improvements in muscular strength for bench press and leg curl exercises compared to placebo.
How They Measured It
Body measurements, skin fold thickness, muscular strength (bench press, leg curl)
To evaluate the effects of gamma-oryzanol supplementation on performance and physiological parameters during resistance exercise training.
Study Type
Randomized controlled trial
Purpose
To evaluate the effects of gamma-oryzanol supplementation on performance and physiological parameters during resistance exercise training.
Dose
500 mg/day gamma-oryzanol
Participants
Weight-trained males
Duration
9 weeks
Results
Both supplemented and control groups showed similar increases in strength and vertical jump power with no differences between groups. No effects on hormone levels (testosterone, cortisol, GH), blood lipids, or cardiovascular variables. Gamma-oryzanol did not influence performance in moderately trained males.
How They Measured It
Bench press strength, squat strength, vertical jump power, hormone levels (testosterone, cortisol, growth hormone), blood lipids
Menopausal Symptoms
To evaluate the clinical efficacy of gamma-oryzanol combined with Femoston for perimenopausal syndrome.
Study Type
Retrospective comparative study
Purpose
To evaluate the clinical efficacy of gamma-oryzanol combined with Femoston for perimenopausal syndrome.
Dose
Gamma-oryzanol 10 mg three times daily
Participants
119 patients (59 control/Femoston only, 60 observation/combination)
Duration
12 weeks
Results
Combination therapy achieved 93.33% total effectiveness vs 71.19% for Femoston alone. Lower adverse events (3.33% vs 15.25%). Higher post-treatment estradiol and bone mineral density. Improved sleep quality with longer sleep time and fewer nighttime awakenings.
How They Measured It
Clinical effectiveness rate, estradiol levels, bone mineral density, sleep quality metrics
Metabolic Health & Diabetes
To evaluate the effects of gamma-oryzanol-fortified canola oil on cardiometabolic biomarkers in adults with type 2 diabetes.
Study Type
Randomized controlled trial
Purpose
To evaluate the effects of gamma-oryzanol-fortified canola oil on cardiometabolic biomarkers in adults with type 2 diabetes.
Dose
Daily consumption of gamma-oryzanol-fortified canola oil vs unfortified canola or sunflower oil
Participants
92 adults with type 2 diabetes (3 groups: n=30, 32, 30)
Duration
12 weeks
Results
Gamma-oryzanol-fortified canola oil group showed significant decreases in fasting blood glucose (-7.7 mg/dL), HbA1c (-0.7%), blood pressure, waist circumference (-2.6 cm), and triglycerides (-17.9 mg/dL). Superior to plain canola and sunflower oil groups.
How They Measured It
Fasting blood glucose, HbA1c, blood pressure, waist circumference, triglycerides, BMI
To evaluate the anti-inflammatory effects of gamma-oryzanol-fortified canola oil in adults with type 2 diabetes.
Study Type
Randomized controlled trial
Purpose
To evaluate the anti-inflammatory effects of gamma-oryzanol-fortified canola oil in adults with type 2 diabetes.
Dose
Daily intake of gamma-oryzanol-fortified canola oil vs unfortified canola or sunflower oil
Participants
92 adults with type 2 diabetes (3 groups: n=30, 32, 30)
Duration
12 weeks
Results
Fortified canola oil group showed most significant reduction in CRP (3.1 to 1.2 mg/L). Interferon-gamma decreased significantly only in fortified group. IL-6 declined in both canola groups. Salivary immune markers increased across all groups.
How They Measured It
C-reactive protein, interferon-gamma, interleukin-6, salivary immune markers
Hormonal & Endocrine Effects
To evaluate the effect of gamma-oryzanol on serum TSH concentrations in patients with primary hypothyroidism.
Study Type
Clinical trial (acute and chronic treatment phases)
Purpose
To evaluate the effect of gamma-oryzanol on serum TSH concentrations in patients with primary hypothyroidism.
Dose
300 mg single oral dose (acute); chronic dosing (not specified)
Participants
8 patients with primary hypothyroidism
Duration
Single dose study plus chronic treatment phase
Results
Single 300 mg dose produced significant reduction in elevated serum TSH levels. Chronic treatment decreased serum TSH in 6 of 8 patients. No changes in thyroxine-iodine or triiodothyronine. Suggests action at hypothalamic rather than pituitary level.
How They Measured It
Serum TSH levels, thyroxine-iodine, triiodothyronine
Frequently Asked Questions
Common questions about Gamma Oryzanol research
There are currently 9 peer-reviewed studies on Gamma Oryzanol (Gamma-Oryzanol (γ-Oryzanol)), involving 450 total participants. Research covers Cholesterol management, Sports performance, Antioxidant. The overall evidence strength is rated as Moderate.
The evidence is currently rated as "Moderate Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (9 human studies), and reported outcomes.
Gamma Oryzanol has been researched for: Cholesterol management, Sports performance, Antioxidant. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 9 out of 9 studies are human trials. Human trials carry more weight in our evidence scoring system.
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