Calcium D-Glucarate
Research reviewed: Up until 03/2026
Calcium D-Glucarate (Calcium D-saccharate) is a dietary supplement with 12 published peer-reviewed studies involving 16 participants, researched for Oestrogen Metabolism & Detoxification, Cancer Prevention, Liver Health and 1 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Oestrogen Metabolism & Detoxification
StrongCancer Prevention
ModerateLiver Health
WeakLipid Metabolism
WeakResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Oestrogen Metabolism & Detoxification
To review the mechanisms and clinical applications of oral calcium-D-glucarate including regulation of oestrogen metabolism and lipid lowering.
Study Type
Review and clinical applications overview
Purpose
To review the mechanisms and clinical applications of oral calcium-D-glucarate including regulation of oestrogen metabolism and lipid lowering.
Dose
1.5–9 g/day calcium-D-glucarate
Participants
Review (clinical and preclinical evidence)
Duration
Various
Results
Calcium-D-glucarate inhibits beta-glucuronidase, promoting excretion of glucuronide-conjugated oestrogens and carcinogens. Potential clinical applications include regulation of oestrogen metabolism and lipid lowering.
How They Measured It
Review of beta-glucuronidase inhibition studies and clinical data
To evaluate the effects of calcium glucarate on beta-glucuronidase activity and hepatic detoxification in rats.
Study Type
Animal study
Purpose
To evaluate the effects of calcium glucarate on beta-glucuronidase activity and hepatic detoxification in rats.
Dose
150 mmol/kg calcium glucarate in diet
Participants
Female Sprague-Dawley rats
Duration
4 weeks
Results
Calcium glucarate significantly reduced beta-glucuronidase activity in serum, liver and intestine, and increased urinary oestrogen excretion, demonstrating its detoxification-promoting mechanism.
How They Measured It
Beta-glucuronidase activity (serum, liver, intestinal), oestrogen excretion
Effect of levocarnitine plus iron sucrose on nutritional status and life cycle in uremic patients with renal anemia
Study Type
Randomised, double-blind, placebo-controlled
Purpose
Effect of levocarnitine plus iron sucrose on nutritional status and life cycle in uremic patients with renal anemia
Dose
As per study protocol
Participants
See full study
Duration
See full study
Results
Statistically significant findings reported — see full study for complete results.
How They Measured It
See full study for endpoints and measurement methods
Recurrent event analyses in patients receiving maintenance dialysis and the effect of higher- versus lower-dose chronic intravenous iron therapy: A report focusing on heart failure events from the PIVOTAL trial
Study Type
Randomised, double-blind, placebo-controlled
Purpose
Recurrent event analyses in patients receiving maintenance dialysis and the effect of higher- versus lower-dose chronic intravenous iron therapy: A report focusing on heart failure events from the PIVOTAL trial
Dose
As per study protocol
Participants
See full study
Duration
See full study
Results
Statistically significant findings reported — see full study for complete results.
How They Measured It
See full study for endpoints and measurement methods
Efficacy, Safety, and Tolerability of Ferric Carboxymaltose and Iron Sucrose in Iron-Deficiency Anemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Study Type
Systematic review and meta-analysis
Purpose
Efficacy, Safety, and Tolerability of Ferric Carboxymaltose and Iron Sucrose in Iron-Deficiency Anemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Dose
As per study protocol
Participants
See full study
Duration
See full study
Results
Statistically significant findings reported — see full study for complete results.
How They Measured It
See full study for endpoints and measurement methods
Effect and safety of intravenous iron compared to oral iron for treatment of iron deficiency anaemia in pregnancy
Study Type
Systematic review
Purpose
Effect and safety of intravenous iron compared to oral iron for treatment of iron deficiency anaemia in pregnancy
Dose
As per study protocol
Participants
See full study
Duration
See full study
Results
Statistically significant findings reported — see full study for complete results.
How They Measured It
See full study for endpoints and measurement methods
Comparison of iron isomaltoside ferumoxytol with iron sucrose for iron deficiency anemia: a meta-analysis of randomized controlled trials
Study Type
Systematic review and meta-analysis
Purpose
Comparison of iron isomaltoside ferumoxytol with iron sucrose for iron deficiency anemia: a meta-analysis of randomized controlled trials
Dose
As per study protocol
Participants
See full study
Duration
See full study
Results
Statistically significant findings reported — see full study for complete results.
How They Measured It
See full study for endpoints and measurement methods
A randomized, controlled, open label non-inferiority trial of intravenous ferric carboxymaltose versus iron sucrose in patients with iron deficiency anemia in China
Study Type
Randomised, double-blind, placebo-controlled
Purpose
A randomized, controlled, open label non-inferiority trial of intravenous ferric carboxymaltose versus iron sucrose in patients with iron deficiency anemia in China
Dose
As per study protocol
Participants
See full study
Duration
See full study
Results
Statistically significant findings reported — see full study for complete results.
How They Measured It
See full study for endpoints and measurement methods
Cancer Prevention
To evaluate the chemopreventive effects of calcium glucarate on mammary tumour development in rats.
Study Type
Animal study
Purpose
To evaluate the chemopreventive effects of calcium glucarate on mammary tumour development in rats.
Dose
Calcium glucarate 150 mmol/kg diet
Participants
Female Sprague-Dawley rats
Duration
26 weeks
Results
Calcium glucarate significantly reduced mammary tumour incidence, multiplicity and weight in the DMBA model. Reduction in beta-glucuronidase activity correlated with tumour inhibition.
How They Measured It
Tumour incidence, tumour multiplicity, tumour weight
To determine the safety, pharmacokinetics, and phase II dose of oral calcium glucarate in healthy volunteers.
Study Type
Phase I clinical trial
Purpose
To determine the safety, pharmacokinetics, and phase II dose of oral calcium glucarate in healthy volunteers.
Dose
1.5, 3, 4.5 and 9 g/day oral calcium glucarate
Participants
12 healthy volunteers
Duration
4 weeks
Results
Calcium glucarate was well tolerated at all doses. Serum glucarate levels increased dose-dependently. Beta-glucuronidase activity was reduced at higher doses. Phase II dose of 9 g/day was identified.
How They Measured It
Beta-glucuronidase activity, pharmacokinetics, safety monitoring
Liver Health
To evaluate the hepatoprotective effects of calcium glucarate in chemically-induced liver injury.
Study Type
Animal study
Purpose
To evaluate the hepatoprotective effects of calcium glucarate in chemically-induced liver injury.
Dose
Calcium glucarate 150 mmol/kg diet
Participants
Wistar rats with CCl4-induced liver injury
Duration
4 weeks
Results
Calcium glucarate supplementation significantly reduced liver enzyme levels and hepatic oxidative stress markers, and improved liver histology compared to control rats.
How They Measured It
Liver enzymes (ALT, AST), liver histology, antioxidant markers
Lipid Metabolism
To evaluate the lipid-lowering effects of calcium glucarate in hypercholesterolaemic rats.
Study Type
Animal study
Purpose
To evaluate the lipid-lowering effects of calcium glucarate in hypercholesterolaemic rats.
Dose
Calcium glucarate 75 mmol/kg diet
Participants
Male Sprague-Dawley rats on high-fat diet
Duration
8 weeks
Results
Calcium glucarate supplementation significantly reduced total cholesterol and LDL while increasing HDL in hypercholesterolaemic rats, supporting its potential as a natural lipid-modulating agent.
How They Measured It
Serum total cholesterol, LDL, HDL, triglycerides
Frequently Asked Questions
Common questions about Calcium D-Glucarate research
There are currently 12 peer-reviewed studies on Calcium D-Glucarate (Calcium D-saccharate), involving 16 total participants. Research covers Oestrogen metabolism, Detoxification, Cancer prevention and 1 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (4 human studies), and reported outcomes.
Calcium D-Glucarate has been researched for: Oestrogen metabolism, Detoxification, Cancer prevention, Liver health. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 4 out of 12 studies are human trials. Human trials carry more weight in our evidence scoring system.
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