Withania Coagulans
Research reviewed: Up until 03/2026
Withania Coagulans (Withania coagulans (Indian Rennet / Paneer Dodi)) is a dietary supplement with 8 published peer-reviewed studies involving 44 participants, researched for Blood Sugar & Diabetes, Phytochemistry & Bioactive Properties.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Blood Sugar & Diabetes
ModeratePhytochemistry & Bioactive Properties
WeakResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Blood Sugar & Diabetes
Withania coagulans in management of type II diabetes mellitus
Study Type
Clinical Ayurvedic trial
Purpose
Withania coagulans in management of type II diabetes mellitus
Dose
3g fruit powder twice daily
Participants
40 Type 2 diabetic patients
Duration
3 months
Results
Significant reductions in fasting and postprandial blood glucose. Lipid profile improved. Well tolerated with no adverse effects.
How They Measured It
FBS, PPBS, HbA1c, lipid profile, body weight
Antidiabetic effect of W. coagulans in experimental diabetic rats
Study Type
Preclinical controlled study
Purpose
Antidiabetic effect of W. coagulans in experimental diabetic rats
Dose
Various aqueous extract concentrations
Participants
Diabetic rats
Duration
4 weeks
Results
Significantly lowered blood glucose in all diabetic groups dose-dependently. Chromium and zinc identified as key glycemic elements contributing to hypoglycaemic effect.
How They Measured It
FBS, glucose tolerance test, PPBS; LIBS mineral detection
Hypoglycaemic activity in STZ-induced diabetic rats
Study Type
Animal pharmacological study
Purpose
Hypoglycaemic activity in STZ-induced diabetic rats
Dose
1g/kg aqueous fruit extract
Participants
STZ-diabetic rats
Duration
4 weeks
Results
Significantly lowered blood sugar, serum cholesterol, and lipid peroxidation levels. Demonstrates antidiabetic and antioxidant properties.
How They Measured It
Blood glucose, serum cholesterol, serum and hepatic LPO
Amelioration of dyslipidaemia and oxidative stress in NA-STZ diabetic rats
Study Type
Animal study
Purpose
Amelioration of dyslipidaemia and oxidative stress in NA-STZ diabetic rats
Dose
250mg/kg aqueous extract
Participants
NA-STZ diabetic rats
Duration
30 days
Results
Significantly improved lipid profiles, reduced oxidative stress, and modulated hepatic enzyme activities relevant to cholesterol and fatty acid metabolism.
How They Measured It
Lipid profile, MDA, GSH, SOD, FRAP, HMG CoA reductase activity
Phytochemistry & Bioactive Properties
Comprehensive pharmacological review of W. coagulans
Study Type
Phytochemical review
Purpose
Comprehensive pharmacological review of W. coagulans
Dose
Various
Participants
Review
Duration
Various
Results
Contains withanolides, saponins, alkaloids, steroids with demonstrated antidiabetic, antimicrobial, hepatoprotective, anti-inflammatory, and antioxidant activities. Fruit extract most potent.
How They Measured It
Review of in vitro, in vivo, and clinical studies
Alpha-glucosidase inhibitory activity of W. coagulans compounds
Study Type
In vitro and in vivo study
Purpose
Alpha-glucosidase inhibitory activity of W. coagulans compounds
Dose
Withaferin A and withanolides
Participants
In vitro and animal model
Duration
4 weeks
Results
Withanolides showed significant alpha-glucosidase inhibitory activity comparable to acarbose. Reduced postprandial hyperglycaemia in animal models.
How They Measured It
Alpha-glucosidase inhibition assay, blood glucose
Anti-inflammatory and analgesic properties of W. coagulans extracts
Study Type
Anti-inflammatory study
Purpose
Anti-inflammatory and analgesic properties of W. coagulans extracts
Dose
200-400mg/kg extract
Participants
Animal inflammatory model
Duration
Acute and sub-chronic
Results
Significant anti-inflammatory and analgesic effects in both acute and chronic models via withanolide-mediated NF-kB inhibition.
How They Measured It
Carrageenan paw oedema, TNF-alpha, IL-6
Hepatoprotective activity of W. coagulans fruit extract
Study Type
Hepatoprotective study
Purpose
Hepatoprotective activity of W. coagulans fruit extract
Dose
200-400mg/kg extract
Participants
CCl4-induced hepatotoxic rats
Duration
4 weeks
Results
Significantly reduced liver enzymes. Hepatoprotective activity comparable to silymarin confirmed by histopathological examination.
How They Measured It
ALT, AST, ALP, histopathology
Frequently Asked Questions
Common questions about Withania Coagulans research
There are currently 8 peer-reviewed studies on Withania Coagulans (Withania coagulans (Indian Rennet / Paneer Dodi)), involving 44 total participants. Research covers Blood sugar & type 2 diabetes, Lipid profile improvement, Antioxidant & anti-inflammatory and 1 more areas. The overall evidence strength is rated as Moderate.
The evidence is currently rated as "Moderate Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (1 human study), and reported outcomes.
Withania Coagulans has been researched for: Blood sugar & type 2 diabetes, Lipid profile improvement, Antioxidant & anti-inflammatory, Metabolic health. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 1 out of 8 studies are human trials. Human trials carry more weight in our evidence scoring system.
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