Vervain
Research reviewed: Up until 03/2026
Vervain (Verbena officinalis (Common Vervain)) is a dietary supplement with 8 published peer-reviewed studies involving 0 participants, researched for Anti-inflammatory & Analgesic, Metabolic & Neurological Applications.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Anti-inflammatory & Analgesic
WeakMetabolic & Neurological Applications
WeakResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Anti-inflammatory & Analgesic
Anti-inflammatory and analgesic activity of V. officinalis in experimental models
Study Type
Anti-inflammatory and analgesic study
Purpose
Anti-inflammatory and analgesic activity of V. officinalis in experimental models
Dose
50% methanolic extract 200-400mg/kg topical and i.p.
Participants
Animal models of inflammation and pain
Duration
Acute
Results
Significant anti-inflammatory activity in both topical and systemic administration. Analgesic effects confirmed in visceral and thermal pain models.
How They Measured It
Carrageenan paw oedema, acetic acid writhing, hot plate test
Medicinally important properties of Verbena officinalis reviewed
Study Type
Comprehensive review
Purpose
Medicinally important properties of Verbena officinalis reviewed
Dose
Various
Participants
Review
Duration
Various
Results
Antioxidant, antimicrobial, anti-inflammatory, neuroprotective, anticancer, analgesic, and anticonvulsant activities. Verbenalin, hastatoside, verbascoside, and luteolin key bioactives.
How They Measured It
Systematic literature review
Novel neuroprotective effects of V. officinalis aqueous extracts against beta-amyloid
Study Type
Neuroprotective study
Purpose
Novel neuroprotective effects of V. officinalis aqueous extracts against beta-amyloid
Dose
Verbena extract 1-100µg/mL
Participants
Primary cortical neuron cultures
Duration
N/A
Results
Significant neuroprotection against beta-amyloid peptide toxicity and dithiothreitol-induced oxidative stress. Identifies potential for Alzheimer's prevention.
How They Measured It
Beta-amyloid toxicity in cortical neurons, oxidative stress markers
Metabolic & Neurological Applications
Effects of exercise training combined with V. officinalis on metabolic parameters
Study Type
Exercise and preclinical study
Purpose
Effects of exercise training combined with V. officinalis on metabolic parameters
Dose
V. officinalis extract combined with exercise
Participants
Animal model
Duration
8 weeks
Results
Synergistic improvements in metabolic parameters and antioxidant status with combination of exercise and Verbena. Anti-inflammatory and hepatoprotective effects confirmed.
How They Measured It
Metabolic markers, oxidative stress, histological parameters
Key anti-atherosclerotic compounds in Verbena officinalis by computational drug design
Study Type
Antiatherosclerotic computational study
Purpose
Key anti-atherosclerotic compounds in Verbena officinalis by computational drug design
Dose
Identified bioactive compounds
Participants
In silico analysis
Duration
N/A
Results
Luteolin, apigenin, and verbascoside identified as key anti-atherosclerotic compounds via HMGCR, COX-2, and VEGF inhibition.
How They Measured It
Computer-aided drug design, molecular docking against HMGCR, COX-2, VEGF
Antimicrobial activity of V. officinalis against oral and skin pathogens
Study Type
Antimicrobial study
Purpose
Antimicrobial activity of V. officinalis against oral and skin pathogens
Dose
Aqueous and ethanolic extracts
Participants
In vitro microbiology
Duration
N/A
Results
Significant antimicrobial activity against gram-positive, gram-negative bacteria and Candida. Luteolin and verbenalin identified as primary antimicrobial compounds.
How They Measured It
MIC determination, disk diffusion against S. aureus, E. coli, C. albicans
Anticonvulsant properties of Verbena officinalis
Study Type
Anticonvulsant study
Purpose
Anticonvulsant properties of Verbena officinalis
Dose
100-400mg/kg extract
Participants
Animal seizure models
Duration
Acute
Results
Significant anticonvulsant activity in PTZ model via GABA-A receptor potentiation. Confirms traditional use in epilepsy management.
How They Measured It
PTZ-induced seizure model, GABA receptor binding, seizure threshold
Antidepressant-like effects of V. officinalis hastatoside and verbenalin
Study Type
Antidepressant study
Purpose
Antidepressant-like effects of V. officinalis hastatoside and verbenalin
Dose
Hastatoside + verbenalin equivalent
Participants
Animal depression models
Duration
7 days
Results
Significant antidepressant effects comparable to imipramine. Serotonin and noradrenaline augmentation via MAO inhibition identified.
How They Measured It
FST, TST, monoamine levels
Frequently Asked Questions
Common questions about Vervain research
There are currently 8 peer-reviewed studies on Vervain (Verbena officinalis (Common Vervain)), involving 0 total participants. Research covers Anti-inflammatory, Neuroprotective, Antispasmodic & digestive and 1 more areas. The overall evidence strength is rated as Weak.
The evidence is currently rated as "Weak Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (0 human studies), and reported outcomes.
Vervain has been researched for: Anti-inflammatory, Neuroprotective, Antispasmodic & digestive, Antimicrobial. Each area has its own body of evidence which you can explore in the study breakdowns above.
Currently all 8 studies on Vervain are animal or in-vitro studies. Human clinical trials are needed before the evidence can be rated above "Weak".
