Tremella Mushroom
Research reviewed: Up until 03/2026
Tremella Mushroom (Tremella fuciformis) is a dietary supplement with 4 published peer-reviewed studies involving 1,600 participants, researched for Skin Health, Neuroprotection.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Skin Health
ModerateNeuroprotection
WeakResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Skin Health
To review cutaneous benefits of Tremella fuciformis comprehensively.
Study Type
Review - dermatological
Purpose
To review cutaneous benefits of Tremella fuciformis comprehensively.
Dose
N/A - review
Participants
Review of multiple studies
Duration
N/A
Results
Tremella polysaccharides demonstrate superior moisture retention (comparable or better than hyaluronic acid), antioxidant protection, anti-inflammatory effects, and collagen synthesis stimulation. Both oral and topical applications supported.
How They Measured It
Literature review of hydration, antioxidant, anti-inflammatory evidence
To assess Tremella polysaccharide protection of skin fibroblasts from oxidative stress.
Study Type
In vitro study
Purpose
To assess Tremella polysaccharide protection of skin fibroblasts from oxidative stress.
Dose
Tremella polysaccharide at 50-200 ug/mL
Participants
Human dermal fibroblast cell line
Duration
N/A
Results
Tremella polysaccharide protects skin fibroblasts from hydrogen peroxide-induced oxidative damage via SIRT1 upregulation. Reduced apoptosis and improved cell viability.
How They Measured It
Cell viability, SIRT1 expression, oxidative stress markers
Neuroprotection
To investigate neuroprotective effects of Tremella fuciformis in PC12h cells.
Study Type
In vitro study
Purpose
To investigate neuroprotective effects of Tremella fuciformis in PC12h cells.
Dose
Hot water extract at various concentrations
Participants
PC12h neural cell line
Duration
N/A
Results
Tremella extract protected against beta-amyloid 25-35 peptide toxicity and stimulated NGF-induced neurite outgrowth. Potential use in Alzheimer's disease prevention.
How They Measured It
Cell viability, neurite outgrowth, beta-amyloid toxicity assays, NGF stimulation
To compare immunomodulatory and anticancer activities across Tremella fuciformis strains.
Study Type
In vitro comparative study
Purpose
To compare immunomodulatory and anticancer activities across Tremella fuciformis strains.
Dose
Polysaccharide extracts from different strains
Participants
Multiple immune and cancer cell lines
Duration
N/A
Results
All strains showed anticancer, anti-inflammatory, and immunomodulatory effects with significant strain variation. Polysaccharide content was primary determinant of bioactivity.
How They Measured It
Macrophage activation, NK cell activity, cancer cell proliferation inhibition
Frequently Asked Questions
Common questions about Tremella Mushroom research
There are currently 38 peer-reviewed studies on Tremella Mushroom (Tremella fuciformis), involving 1,600 total participants. Research covers Skin health, Brain health, Immune support and 1 more areas. The overall evidence strength is rated as Moderate.
The evidence is currently rated as "Moderate Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (1 human study), and reported outcomes.
Tremella Mushroom has been researched for: Skin health, Brain health, Immune support, Anti-aging. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 1 out of 38 studies are human trials. Human trials carry more weight in our evidence scoring system.
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