Sesamin
Research reviewed: Up until 03/2026
Sesamin (Sesamin (Sesamum indicum lignan)) is a dietary supplement with 3 published peer-reviewed studies involving 75 participants, researched for Cardiovascular & Anti-inflammatory, Cardiovascular & Lipid Health.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Cardiovascular & Anti-inflammatory
StrongCardiovascular & Lipid Health
WeakResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Cardiovascular & Anti-inflammatory
To assess sesamin supplementation on blood pressure and lipid oxidation.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To assess sesamin supplementation on blood pressure and lipid oxidation.
Dose
Sesamin 60mg daily
Participants
45 mildly hypertensive adults
Duration
4 weeks
Results
Sesamin significantly reduced systolic blood pressure (-7 mmHg) and oxidised LDL. Antioxidant status improved. Sesamin increased delta-5 desaturase activity improving omega-3 conversion.
How They Measured It
Blood pressure, oxidised LDL, antioxidant status, lipid profile
To evaluate sesamin effect on plasma alpha-tocopherol levels and antioxidant protection.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate sesamin effect on plasma alpha-tocopherol levels and antioxidant protection.
Dose
Sesamin 15-30mg combined with vitamin E
Participants
30 healthy adults
Duration
6 weeks
Results
Sesamin significantly increased plasma alpha-tocopherol (vitamin E) levels by inhibiting tocopherol-omega-hydroxylase. Synergistic antioxidant protection confirmed.
How They Measured It
Plasma alpha-tocopherol, gamma-tocopherol, oxidative stress markers
Cardiovascular & Lipid Health
To evaluate the effects of sesamin supplementation on obesity, blood pressure, and lipid profile.
Study Type
Systematic Review and Meta-Analysis
Purpose
To evaluate the effects of sesamin supplementation on obesity, blood pressure, and lipid profile.
Dose
Various doses across included trials (typically 500-1000 mg/day)
Participants
Meta-analysis of multiple RCTs
Duration
Various
Results
Sesamin supplementation significantly reduced BMI, waist circumference, systolic blood pressure, LDL cholesterol, and triglycerides compared to placebo.
How They Measured It
Meta-analysis of RCTs; body weight, BMI, blood pressure, LDL, HDL, triglycerides
Frequently Asked Questions
Common questions about Sesamin research
There are currently 3 peer-reviewed studies on Sesamin (Sesamin (Sesamum indicum lignan)), involving 75 total participants. Research covers Cardiovascular health, Anti-inflammatory, Liver health and 1 more areas. The overall evidence strength is rated as Moderate.
The evidence is currently rated as "Moderate Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (2 human studies), and reported outcomes.
Sesamin has been researched for: Cardiovascular health, Anti-inflammatory, Liver health, Antioxidant protection. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 2 out of 3 studies are human trials. Human trials carry more weight in our evidence scoring system.
