Safed Musli
Research reviewed: Up until 03/2026
Safed Musli (Chlorophytum borivilianum) is a dietary supplement with 8 published peer-reviewed studies involving 90 participants, researched for Male Sexual Health & Fertility, Adaptogenic, Immune & Antidiabetic.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Male Sexual Health & Fertility
ModerateAdaptogenic, Immune & Antidiabetic
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Male Sexual Health & Fertility
Root tubers of C. borivilianum on semen and testosterone in oligozoospermic men
Study Type
Clinical evaluation
Purpose
Root tubers of C. borivilianum on semen and testosterone in oligozoospermic men
Dose
2g root powder twice daily
Participants
50 oligozoospermic men
Duration
90 days
Results
Significant improvements in sperm count, motility, and morphology. Testosterone levels increased. Aphrodisiac and spermatogenic claims confirmed.
How They Measured It
Semen analysis (WHO criteria), serum testosterone, LH, FSH
Aphrodisiac potential and safety of standardised C. borivilianum extract
Study Type
Preclinical aphrodisiac study
Purpose
Aphrodisiac potential and safety of standardised C. borivilianum extract
Dose
Standardised saponin extract 250-500mg/kg
Participants
Male Wistar rats
Duration
28 days
Results
Significantly improved sexual behaviour parameters dose-dependently. Safety confirmed. Saponins identified as primary aphrodisiac bioactives.
How They Measured It
Sexual behaviour parameters (mount/intromission frequency, ejaculation latency)
Safed Musli for male infertility in cyproterone acetate-treated rats
Study Type
Male infertility study
Purpose
Safed Musli for male infertility in cyproterone acetate-treated rats
Dose
Hydromethanolic extract 250mg/kg
Participants
Animal infertility model
Duration
60 days
Results
Significantly restored semen parameters and hormonal profiles. Testicular histology showed restoration of spermatogenesis.
How They Measured It
Semen parameters, testosterone, LH, FSH, testicular histology
Adaptogenic, Immune & Antidiabetic
Immunomodulatory activity of C. borivilianum
Study Type
Immunomodulatory study
Purpose
Immunomodulatory activity of C. borivilianum
Dose
200-400mg/kg extract
Participants
Animal immunology model
Duration
28 days
Results
Significantly enhanced humoral and cell-mediated immunity. Immunostimulatory activity comparable to Tinospora cordifolia.
How They Measured It
Humoral and cell-mediated immunity, lymphocyte proliferation, phagocytic activity
Safed Musli protection of sperm against diabetic oxidative stress
Study Type
Sperm protection study
Purpose
Safed Musli protection of sperm against diabetic oxidative stress
Dose
200mg/kg aqueous root extract
Participants
STZ-induced diabetic rats
Duration
60 days
Results
Prevented impairment of sperm characteristics and reduced oxidative stress in sperm from diabetic animals. Male reproductive protection via antioxidant activity.
How They Measured It
Sperm characteristics, morphology, ROS levels
Comprehensive review of C. borivilianum pharmacology
Study Type
Phytochemical review
Purpose
Comprehensive review of C. borivilianum pharmacology
Dose
Various
Participants
Review
Duration
Various
Results
Saponins, polysaccharides, alkaloids, and stigmasterol with aphrodisiac, adaptogenic, immunomodulatory, and antidiabetic activities. Saponin content is primary determinant of biological activity.
How They Measured It
Literature review
Hypoglycaemic activity of C. borivilianum root extract in diabetic mice
Study Type
Antidiabetic study
Purpose
Hypoglycaemic activity of C. borivilianum root extract in diabetic mice
Dose
200mg/kg aqueous extract
Participants
Alloxan-induced diabetic mice
Duration
21 days
Results
Significantly reduced fasting blood glucose comparable to metformin at tested doses. Active saponins may act via insulin sensitisation.
How They Measured It
FBS, glucose tolerance test
Adaptogenic and anabolic properties of Safed Musli in athletes
Study Type
Adaptogenic clinical pilot
Purpose
Adaptogenic and anabolic properties of Safed Musli in athletes
Dose
2g root powder daily
Participants
40 healthy male athletes
Duration
8 weeks
Results
Improved aerobic capacity, testosterone levels, and reduced exercise-induced fatigue. Supports Vajikaran (vitality tonic) classification.
How They Measured It
VO2 max, testosterone, fatigue scores, recovery markers
Frequently Asked Questions
Common questions about Safed Musli research
There are currently 8 peer-reviewed studies on Safed Musli (Chlorophytum borivilianum), involving 90 total participants. Research covers Male sexual health & fertility, Adaptogenic & vitality, Immune support and 1 more areas. The overall evidence strength is rated as Moderate.
The evidence is currently rated as "Moderate Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (2 human studies), and reported outcomes.
Safed Musli has been researched for: Male sexual health & fertility, Adaptogenic & vitality, Immune support, Antidiabetic. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 2 out of 8 studies are human trials. Human trials carry more weight in our evidence scoring system.
