Royal Jelly
Research reviewed: Up until 03/2026
Royal Jelly (Apis mellifera royal jelly) is a dietary supplement with 6 published peer-reviewed studies involving 97 participants, researched for Energy, Vitality & Hormonal Balance, General Health & Wellbeing, Antioxidant & Cellular Health.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Energy, Vitality & Hormonal Balance
ModerateGeneral Health & Wellbeing
ModerateAntioxidant & Cellular Health
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Energy, Vitality & Hormonal Balance
To assess royal jelly on general health, mood, and wellbeing in healthy adults.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To assess royal jelly on general health, mood, and wellbeing in healthy adults.
Dose
Royal jelly 3000mg daily
Participants
61 healthy adults
Duration
6 months
Results
Royal jelly significantly improved health-related quality of life, reduced fatigue, and improved mental health subscales. Borderline lipid profile improvements observed.
How They Measured It
Quality of life questionnaire, fatigue score, immune markers, lipid profile
To evaluate royal jelly in perimenopausal women for hormonal and cognitive effects.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate royal jelly in perimenopausal women for hormonal and cognitive effects.
Dose
Royal jelly 800mg daily
Participants
36 perimenopausal women
Duration
3 months
Results
Royal jelly improved memory, concentration, and reduced menopausal symptoms. Mild estrogenic-like effects. Improved HDL cholesterol. No serious adverse effects.
How They Measured It
Menopausal symptom questionnaire, cognitive tests, lipid profile
General Health & Wellbeing
To investigate whether royal jelly supplementation improves high-intensity interval exercise performance in competitive swimmers.
Study Type
Randomized, Double-Blind, Placebo-Controlled
Purpose
To investigate whether royal jelly supplementation improves high-intensity interval exercise performance in competitive swimmers.
Dose
Royal jelly 1000 mg/day plus coenzyme Q10
Participants
24 competitive swimmers
Duration
8 weeks
Results
Royal jelly plus CoQ10 supplementation improved exercise performance and reduced markers of oxidative stress and muscle damage compared to placebo.
How They Measured It
Swim performance tests, oxidative stress biomarkers (MDA, SOD), muscle damage markers (CK, LDH)
To evaluate the effects of royal jelly supplementation on liver enzymes and glycemic indices.
Study Type
Systematic Review and Meta-Analysis
Purpose
To evaluate the effects of royal jelly supplementation on liver enzymes and glycemic indices.
Dose
Various doses across included trials
Participants
Meta-analysis of multiple RCTs
Duration
Various
Results
Royal jelly supplementation significantly reduced fasting blood glucose and liver enzymes (ALT, AST) compared to placebo.
How They Measured It
Meta-analysis of randomized clinical trials; liver enzymes (ALT, AST), glucose, insulin, HbA1c
To evaluate the effect of protease-treated royal jelly extract on facial wrinkles.
Study Type
Randomized, Double-Blind, Placebo-Controlled
Purpose
To evaluate the effect of protease-treated royal jelly extract on facial wrinkles.
Dose
Protease-treated royal jelly extract oral supplement
Participants
Healthy adults with facial wrinkles
Duration
12 weeks
Results
Protease-treated royal jelly extract supplementation significantly reduced wrinkle area and depth compared to placebo.
How They Measured It
Skin wrinkle measurements, photographic assessment, skin elasticity measurements
Antioxidant & Cellular Health
To investigate the effect of royal jelly supplementation on oxidative stress, antioxidant markers and physical activities in patients with multiple sclerosis.
Study Type
Randomized, Double-Blind, Placebo-Controlled
Purpose
To investigate the effect of royal jelly supplementation on oxidative stress, antioxidant markers and physical activities in patients with multiple sclerosis.
Dose
1000 mg royal jelly daily
Participants
Multiple sclerosis patients
Duration
8 weeks
Results
Royal jelly significantly improved antioxidant markers and reduced oxidative stress in MS patients, along with improvements in physical activity parameters.
How They Measured It
Oxidative stress biomarkers, antioxidant capacity, physical activity assessment
Frequently Asked Questions
Common questions about Royal Jelly research
There are currently 6 peer-reviewed studies on Royal Jelly (Apis mellifera royal jelly), involving 97 total participants. Research covers Energy & vitality, Immune support, Hormonal balance and 1 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (5 human studies), and reported outcomes.
Royal Jelly has been researched for: Energy & vitality, Immune support, Hormonal balance, Anti-aging. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 5 out of 6 studies are human trials. Human trials carry more weight in our evidence scoring system.
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