Rehmannia
Research reviewed: Up until 03/2026
Rehmannia (Rehmannia glutinosa) is a dietary supplement with 10 published peer-reviewed studies involving 0 participants, researched for Kidney Support, Bone Health, Anti-Aging and 1 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Kidney Support
WeakBone Health
WeakAnti-Aging
WeakKidney & Metabolic Health
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Kidney Support
To assess Rehmannia on diabetic nephropathy and kidney protection
Study Type
Animal study
Purpose
To assess Rehmannia on diabetic nephropathy and kidney protection
Dose
RG extract supplementation
Participants
Diabetic rats
Duration
12 weeks
Results
Rehmannia glutinosa significantly improved GFR, reduced proteinuria, and preserved kidney histology in diabetic nephropathy model. Anti-inflammatory and antioxidant mechanisms identified.
How They Measured It
GFR, urinary protein, kidney histology
To review pharmacological effects and clinical applications of Rehmanniae Radix
Study Type
Review
Purpose
To review pharmacological effects and clinical applications of Rehmanniae Radix
Dose
Various
Participants
N/A
Duration
N/A
Results
Rehmannia demonstrated significant benefits for kidney function, bone health, neuroprotection, and anti-aging. Catalpol identified as key bioactive compound. PMID: 37995764
How They Measured It
Comprehensive review of clinical and preclinical evidence
To investigate Rehmannia on kidney injury recovery and tubular regeneration
Study Type
Animal study
Purpose
To investigate Rehmannia on kidney injury recovery and tubular regeneration
Dose
RG root extract
Participants
Rats with kidney injury
Duration
3 weeks
Results
Rehmannia treatment reduced plasma urea and creatinine, alleviated inflammation, and facilitated nephron regeneration and new renal tubule formation. PMCID: PMC12029721
How They Measured It
Plasma urea, creatinine, renal histology, inflammatory markers
Bone Health
To assess dried root of Rehmannia glutinosa on bone loss in ovariectomized rats
Study Type
Animal study
Purpose
To assess dried root of Rehmannia glutinosa on bone loss in ovariectomized rats
Dose
200-600 mg/kg dried RG root
Participants
Ovariectomized rats
Duration
12 weeks
Results
Rehmannia glutinosa significantly prevented bone loss and maintained bone mineral density in ovariectomized rats, supporting traditional kidney-tonifying bone health use. PMID: 23685937
How They Measured It
Bone mineral density, trabecular bone morphometry, bone markers
To investigate Rehmannia on glucocorticoid-induced osteoporosis via metabolomics
Study Type
Metabolomics study
Purpose
To investigate Rehmannia on glucocorticoid-induced osteoporosis via metabolomics
Dose
Rehmanniae Radix Preparata extract
Participants
Rats with steroid-induced osteoporosis
Duration
8 weeks
Results
Rehmannia protected against glucocorticoid-induced osteoporosis primarily via modulation of steroid hormone biosynthesis pathways. PMCID: PMC6358733
How They Measured It
Bone density, metabolomics profiling, steroid hormone biosynthesis pathways
Anti-Aging
To assess Rehmannia anti-aging effects via hematopoietic stem cell maintenance
Study Type
Animal study
Purpose
To assess Rehmannia anti-aging effects via hematopoietic stem cell maintenance
Dose
200 mg/day ground RG
Participants
Aged mice
Duration
6 months
Results
Rehmannia supplementation maintained hematopoietic stem cell quiescence and decreased cellular senescence, contributing to systemic anti-aging effects. PMID: 30891565
How They Measured It
HSC populations, senescence markers, aging phenotypes
To investigate catalpol from Rehmannia on Alzheimer's disease neuroprotection
Study Type
Animal study
Purpose
To investigate catalpol from Rehmannia on Alzheimer's disease neuroprotection
Dose
5-10 mg/kg catalpol
Participants
Transgenic AD mice
Duration
4 months
Results
Catalpol from Rehmannia significantly reduced amyloid-beta and tau pathology, reduced neuroinflammation, and improved cognitive performance in AD mice.
How They Measured It
Memory tests, amyloid-beta, tau, neuroinflammation
To review Rehmannia traditional Chinese medicine applications and modern pharmacological evidence
Study Type
Review
Purpose
To review Rehmannia traditional Chinese medicine applications and modern pharmacological evidence
Dose
Various
Participants
N/A
Duration
N/A
Results
Rehmannia glutinosa exhibits anti-aging, kidney-tonifying, bone-strengthening, and neuroprotective effects. Catalpol, acteoside, and polysaccharides are key bioactive compounds. PMCID: PMC6388079
How They Measured It
Comprehensive literature review
Kidney & Metabolic Health
To evaluate add-on Rehmannia-6-based Chinese medicine in type 2 diabetes with CKD.
Study Type
Randomized Controlled Trial (Multicenter)
Purpose
To evaluate add-on Rehmannia-6-based Chinese medicine in type 2 diabetes with CKD.
Dose
Rehmannia-6 formula (Liu Wei Di Huang Wan) standardized extract
Participants
230 patients with type 2 diabetes and chronic kidney disease
Duration
48 weeks
Results
Add-on Rehmannia-6 Chinese medicine significantly slowed CKD progression and improved glycemic control compared to standard treatment alone.
How They Measured It
eGFR, serum creatinine, HbA1c, urinary albumin-creatinine ratio
To evaluate the effects of Rehmannia glutinosa for perimenopausal syndrome in patients with breast cancer.
Study Type
Systematic Review and Meta-Analysis
Purpose
To evaluate the effects of Rehmannia glutinosa for perimenopausal syndrome in patients with breast cancer.
Dose
Various Rehmannia formulations across included studies
Participants
Meta-analysis of breast cancer patients with perimenopausal syndrome
Duration
Various
Results
Rehmannia glutinosa-based treatments significantly reduced perimenopausal symptoms and improved quality of life in breast cancer patients.
How They Measured It
Meta-analysis of RCTs; menopausal symptom scores, quality of life, hormonal parameters
Frequently Asked Questions
Common questions about Rehmannia research
There are currently 10 peer-reviewed studies on Rehmannia (Rehmannia glutinosa), involving 0 total participants. Research covers Kidney support, Bone health, Anti-aging. The overall evidence strength is rated as Moderate.
The evidence is currently rated as "Moderate Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (1 human study, 6 animal studies), and reported outcomes.
Rehmannia has been researched for: Kidney support, Bone health, Anti-aging. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 1 out of 10 studies are human trials. The remaining 6 are animal studies. Human trials carry more weight in our evidence scoring system.
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