Pine Pollen
Research reviewed: Up until 03/2026
Pine Pollen (Pinus pollen) is a dietary supplement with 7 published peer-reviewed studies involving 0 participants, researched for Hormonal Support, Antioxidant & Anti-aging, Immune Function and 1 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Hormonal Support
WeakAntioxidant & Anti-aging
WeakImmune Function
WeakAnti-inflammatory
WeakResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Hormonal Support
To identify and quantify androgens including testosterone, epitestosterone and androstenedione in Scotch pine pollen.
Study Type
Analytical chemistry study
Purpose
To identify and quantify androgens including testosterone, epitestosterone and androstenedione in Scotch pine pollen.
Dose
N/A (analytical study)
Participants
In vitro / analytical
Duration
N/A
Results
Testosterone, epitestosterone and androstenedione were detected and quantified in Pinus silvestris pollen, confirming the presence of mammalian-type androgens in pine pollen.
How They Measured It
Gas chromatography–mass spectrometry
To comprehensively analyse pharmacological and clinical research on pine pollen (Pinus pollen) including hormonal and anti-aging effects.
Study Type
Bibliometric analysis and review
Purpose
To comprehensively analyse pharmacological and clinical research on pine pollen (Pinus pollen) including hormonal and anti-aging effects.
Dose
Various
Participants
Systematic review / bibliometric
Duration
Various
Results
Pine pollen demonstrated multiple health functions including immune regulation, anti-aging, antioxidation, liver protection, inhibition of prostate hyperplasia, and anti-fatigue effects. Phytoandrogenic constituents including testosterone and DHEA were identified.
How They Measured It
Bibliometric analysis of peer-reviewed literature
Antioxidant & Anti-aging
To evaluate the anti-aging effects of pine pollen in human diploid fibroblasts and in a D-galactose-induced mouse aging model.
Study Type
In vitro and animal model study
Purpose
To evaluate the anti-aging effects of pine pollen in human diploid fibroblasts and in a D-galactose-induced mouse aging model.
Dose
Pine pollen extract at 50–200 mg/kg in mice
Participants
Human diploid fibroblasts + D-galactose mouse model
Duration
8 weeks (animal), in vitro
Results
Pine pollen significantly extended cell lifespan, reduced oxidative stress markers, inhibited AGE formation, and reversed aging phenotypes in the mouse model. Results were comparable to aminoguanidine.
How They Measured It
Cell viability, oxidative stress markers (MDA, SOD, CAT), AGEs levels, aging phenotype scoring
To evaluate the antioxidant and anti-inflammatory activity of pine pollen extract.
Study Type
In vitro study
Purpose
To evaluate the antioxidant and anti-inflammatory activity of pine pollen extract.
Dose
Various concentrations of pine pollen extract
Participants
In vitro (cell-free and cell-based assays)
Duration
N/A
Results
Pine pollen extract displayed strong free radical scavenging activity against DPPH and hydrogen peroxide. Anti-inflammatory activity was demonstrated through cyclooxygenase inhibition.
How They Measured It
DPPH radical scavenging assay, H2O2 assay, COX inhibition
Immune Function
To investigate the immunomodulatory effects of pine pollen polysaccharides on macrophage activation.
Study Type
Animal study
Purpose
To investigate the immunomodulatory effects of pine pollen polysaccharides on macrophage activation.
Dose
Pine pollen polysaccharides 50–200 mg/kg
Participants
Mouse macrophage cell lines
Duration
In vitro / short term
Results
Pine pollen polysaccharides stimulated macrophage activation, enhanced phagocytic activity, and promoted production of immunomodulatory cytokines including TNF-α and IL-6.
How They Measured It
Cytokine production (TNF-α, IL-6, IL-12), phagocytic activity
Anti-inflammatory
To evaluate the anti-inflammatory effects of pine pollen wall-broken extract in a liver injury model.
Study Type
Animal study
Purpose
To evaluate the anti-inflammatory effects of pine pollen wall-broken extract in a liver injury model.
Dose
Pine pollen extract 100–400 mg/kg
Participants
Male Sprague-Dawley rats with alcohol-induced liver injury
Duration
8 weeks
Results
Pine pollen extract significantly reduced ALT and AST levels, suppressed hepatic inflammation, and improved liver histology compared to controls. Antioxidant enzyme activities were increased.
How They Measured It
Liver enzymes (AST, ALT), inflammatory cytokines, histology
To investigate the effect of pine pollen on fatigue and exercise performance.
Study Type
Animal study
Purpose
To investigate the effect of pine pollen on fatigue and exercise performance.
Dose
Pine pollen 100, 200, 400 mg/kg
Participants
Male Kunming mice
Duration
4 weeks
Results
Pine pollen supplementation significantly prolonged swimming time to exhaustion, reduced serum lactic acid and blood urea nitrogen, and increased liver glycogen stores, indicating anti-fatigue properties.
How They Measured It
Swimming exhaustion time, blood lactic acid, blood urea nitrogen, liver glycogen
Frequently Asked Questions
Common questions about Pine Pollen research
There are currently 7 peer-reviewed studies on Pine Pollen (Pinus pollen), involving 0 total participants. Research covers Hormonal support, Antioxidant & anti-aging, Immune function and 1 more areas. The overall evidence strength is rated as Weak.
The evidence is currently rated as "Weak Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (0 human studies), and reported outcomes.
Pine Pollen has been researched for: Hormonal support, Antioxidant & anti-aging, Immune function, Anti-inflammatory. Each area has its own body of evidence which you can explore in the study breakdowns above.
Currently all 7 studies on Pine Pollen are animal or in-vitro studies. Human clinical trials are needed before the evidence can be rated above "Weak".
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