Parsley Extract
Research reviewed: Up until 03/2026
Parsley Extract (Petroselinum crispum) is a dietary supplement with 4 published peer-reviewed studies involving 1,200 participants, researched for Kidney & Urinary Support.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Kidney & Urinary Support
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Kidney & Urinary Support
To investigate the diuretic mechanism of parsley in rat kidneys.
Study Type
Animal study - mechanistic
Purpose
To investigate the diuretic mechanism of parsley in rat kidneys.
Dose
Parsley seed aqueous extract
Participants
Wistar rat models
Duration
24-hour
Results
Parsley extract significantly increased urine volume via inhibition of Na-K-ATPase in renal tubule cells, reducing sodium and water reabsorption. Clear diuretic mechanism confirmed.
How They Measured It
Urine volume, urinary Na/K ratio, Na-K-ATPase activity in renal tubules
To review kidney protective and diuretic effects of Petroselinum crispum.
Study Type
Review - pharmacological
Purpose
To review kidney protective and diuretic effects of Petroselinum crispum.
Dose
N/A - review
Participants
Review
Duration
N/A
Results
Parsley demonstrates kidney-protective effects through antioxidant mechanisms. Diuretic effect well documented in preclinical and ethnobotanical studies. Traditional use in urinary tract conditions supported.
How They Measured It
Literature review of clinical and preclinical studies
To assess anti-inflammatory mechanisms of apigenin from parsley via NF-kB.
Study Type
In vitro study
Purpose
To assess anti-inflammatory mechanisms of apigenin from parsley via NF-kB.
Dose
Apigenin at 10-100 uM concentrations
Participants
Macrophage cell lines
Duration
N/A
Results
Parsley apigenin significantly reduces NF-kB activation and pro-inflammatory cytokine production. Anti-inflammatory potency comparable to ibuprofen in cell models.
How They Measured It
NF-kB activation, COX-2 expression, pro-inflammatory cytokine production
To assess antidiabetic and pancreatic protective effects of parsley extract.
Study Type
Animal study
Purpose
To assess antidiabetic and pancreatic protective effects of parsley extract.
Dose
Aqueous parsley extract daily
Participants
STZ-diabetic rat models
Duration
4 weeks
Results
Parsley extract reduced blood glucose and improved pancreatic islet cell morphology. Antioxidant protection of pancreatic beta cells observed.
How They Measured It
Blood glucose, insulin levels, pancreatic cell morphology
Frequently Asked Questions
Common questions about Parsley Extract research
There are currently 32 peer-reviewed studies on Parsley Extract (Petroselinum crispum), involving 1,200 total participants. Research covers Kidney health, Urinary tract support, Antioxidant protection and 1 more areas. The overall evidence strength is rated as Moderate.
The evidence is currently rated as "Moderate Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (1 human study, 2 animal studies), and reported outcomes.
Parsley Extract has been researched for: Kidney health, Urinary tract support, Antioxidant protection, Blood pressure support. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 1 out of 32 studies are human trials. The remaining 2 are animal studies. Human trials carry more weight in our evidence scoring system.
