Pantethine
Research reviewed: Up until 03/2026
Pantethine (Pantethine (Vitamin B5 derivative)) is a dietary supplement with 3 published peer-reviewed studies involving 152 participants, researched for Cholesterol Management, Cardiovascular Health.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Cholesterol Management
StrongCardiovascular Health
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Cholesterol Management
To evaluate pantethine supplementation on LDL cholesterol metabolism in low-to-moderate cardiovascular risk subjects
Study Type
Randomized, triple-blinded, placebo and diet-controlled
Purpose
To evaluate pantethine supplementation on LDL cholesterol metabolism in low-to-moderate cardiovascular risk subjects
Dose
Pantethine 600 mg/day weeks 1-8, 900 mg/day weeks 9-16
Participants
120 subjects with low-to-moderate CVD risk
Duration
16 weeks
Results
Pantethine demonstrated significant reductions in total cholesterol (6 mg/dL, 3%), LDL-C (4 mg/dL, 4%), and apolipoprotein B (5%) vs placebo.
How They Measured It
Total cholesterol, LDL-C, apolipoprotein B
To evaluate pantethine on cholesterol in subjects eligible for statin therapy
Study Type
Randomized, triple-blinded, placebo and diet-controlled
Purpose
To evaluate pantethine on cholesterol in subjects eligible for statin therapy
Dose
Pantethine 600 mg/day weeks 1-8, 900 mg/day weeks 9-16
Participants
32 subjects eligible for statin therapy by NCEP guidelines
Duration
16 weeks
Results
Pantethine showed significant decreases in total cholesterol at 16 weeks and LDL-C at 8 and 16 weeks (p<0.05).
How They Measured It
Total cholesterol, LDL-C, non-HDL cholesterol
Cardiovascular Health
To review pantethine's role in cardiovascular health and cholesterol management
Study Type
Review
Purpose
To review pantethine's role in cardiovascular health and cholesterol management
Dose
Typical 600-900 mg/day
Participants
Multiple study populations
Duration
8-16 weeks typical
Results
Pantethine supplementation for 16 weeks is safe and significantly lowers total and LDL cholesterol over and above TLC diet effects.
How They Measured It
Literature synthesis of clinical trial data
Frequently Asked Questions
Common questions about Pantethine research
There are currently 4 peer-reviewed studies on Pantethine (Pantethine (Vitamin B5 derivative)), involving 152 total participants. Research covers Cholesterol, Cardiovascular health, Metabolic health. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (3 human studies), and reported outcomes.
Pantethine has been researched for: Cholesterol, Cardiovascular health, Metabolic health. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 3 out of 4 studies are human trials. Human trials carry more weight in our evidence scoring system.
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