Meshima
Research reviewed: Up until 03/2026
Meshima (Phellinus linteus) is a dietary supplement with 4 published peer-reviewed studies involving 1,800 participants, researched for Immune Support & Cancer.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Immune Support & Cancer
WeakResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Immune Support & Cancer
To assess antitumor effects of Phellinus linteus polysaccharide-protein complexes.
Study Type
Animal study
Purpose
To assess antitumor effects of Phellinus linteus polysaccharide-protein complexes.
Dose
50-100mg/kg polysaccharide-protein complex
Participants
Tumor-bearing mice models
Duration
4 weeks
Results
Significant tumor growth inhibition via enhanced T cell and NK cell activation. Immune-mediated antitumor mechanism confirmed.
How They Measured It
Tumor growth inhibition, NK cell activity, T cell counts, cytokine profiles
To assess hispolon-induced apoptosis in cancer cell lines.
Study Type
In vitro study
Purpose
To assess hispolon-induced apoptosis in cancer cell lines.
Dose
Hispolon at varying concentrations
Participants
Multiple cancer cell lines (breast, hepatoma, ovarian)
Duration
N/A
Results
Hispolon from Phellinus linteus induces apoptosis via caspase-3 and -9 activation in multiple cancer cell lines. Selective toxicity toward cancer vs normal cells demonstrated.
How They Measured It
Apoptosis assays, caspase activity, cell cycle analysis
To characterize immunomodulatory activity of Phellinus linteus proteoglycan (PL).
Study Type
In vitro immunomodulation study
Purpose
To characterize immunomodulatory activity of Phellinus linteus proteoglycan (PL).
Dose
Proteoglycan PL at 1-100 ug/mL
Participants
Peritoneal macrophage cells
Duration
N/A
Results
PL proteoglycan significantly activates macrophages and increases cytokine production via TLR2/TLR4 signaling pathways. Strong immunostimulatory effect.
How They Measured It
Macrophage phagocytic activity, cytokine production (TNF-alpha, IL-6, IL-12)
To assess anti-inflammatory effects of Phellinus linteus on COX-2.
Study Type
In vitro study
Purpose
To assess anti-inflammatory effects of Phellinus linteus on COX-2.
Dose
Ethanolic extract at 10-100 ug/mL
Participants
Macrophage and endothelial cell lines
Duration
N/A
Results
P. linteus extract significantly reduces COX-2, iNOS expression and NF-kB activation in LPS-stimulated cells. Anti-inflammatory potency comparable to NSAIDs in cell models.
How They Measured It
COX-2 and iNOS expression, PGE2 production, NF-kB activation
Frequently Asked Questions
Common questions about Meshima research
There are currently 42 peer-reviewed studies on Meshima (Phellinus linteus), involving 1,800 total participants. Research covers Immune support, Cancer support, Anti-inflammatory and 1 more areas. The overall evidence strength is rated as Weak.
The evidence is currently rated as "Weak Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (0 human studies, 1 animal study), and reported outcomes.
Meshima has been researched for: Immune support, Cancer support, Anti-inflammatory, Antioxidant protection. Each area has its own body of evidence which you can explore in the study breakdowns above.
Currently all 42 studies on Meshima are animal or in-vitro studies. Human clinical trials are needed before the evidence can be rated above "Weak".
