Magnesium Orotate
Research reviewed: 2024-2024
Magnesium Orotate (Magnesium orotate (C₁₀H₆MgN₄O₈)) is a dietary supplement with 8 published peer-reviewed studies involving 120 participants, researched for Heart Failure & Cardiovascular, Exercise Performance, Electrolyte & Metabolic and 1 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Heart Failure & Cardiovascular
StrongExercise Performance
ModerateElectrolyte & Metabolic
ModerateMood & Mental Health
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Heart Failure & Cardiovascular
To evaluate magnesium orotate as adjunct therapy in severe congestive heart failure.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate magnesium orotate as adjunct therapy in severe congestive heart failure.
Dose
6000 mg/day (first month), then 3000 mg/day maintenance
Participants
79 patients with NYHA class III-IV heart failure
Duration
12 months
Results
Magnesium orotate significantly improved 1-year survival (75.7% vs 51.6% placebo). Clinical symptoms and quality of life improved significantly in the treatment group.
How They Measured It
1-year survival rate, clinical symptom improvement, quality of life
To evaluate magnesium orotate on exercise capacity in heart failure patients.
Study Type
Open-label clinical study
Purpose
To evaluate magnesium orotate on exercise capacity in heart failure patients.
Dose
3000 mg/day magnesium orotate
Participants
40 patients with NYHA class II-III heart failure
Duration
6 months
Results
Magnesium orotate significantly improved 6-minute walk distance and showed trends towards improved LVEF and reduced NT-proBNP levels.
How They Measured It
6-minute walk test, LVEF (echocardiography), NT-proBNP
To evaluate magnesium orotate on cardiac arrhythmia reduction post-cardiac surgery.
Study Type
Retrospective cohort study
Purpose
To evaluate magnesium orotate on cardiac arrhythmia reduction post-cardiac surgery.
Dose
3000 mg/day magnesium orotate
Participants
120 patients post-CABG surgery
Duration
6 weeks post-operative
Results
Patients receiving magnesium orotate had significantly lower incidence of post-operative atrial fibrillation (12% vs 28% control).
How They Measured It
Incidence of atrial fibrillation, ventricular arrhythmias
Exercise Performance
To evaluate magnesium orotate on exercise performance in triathletes.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate magnesium orotate on exercise performance in triathletes.
Dose
3000 mg/day magnesium orotate (195 mg elemental Mg)
Participants
23 competitive triathletes
Duration
4 weeks before competition
Results
Magnesium orotate group showed significantly improved swimming, cycling, and running times. Serum glucose and cortisol were lower during exercise in the Mg group.
How They Measured It
Swimming, cycling, and running times; blood glucose; cortisol; insulin
To assess magnesium orotate on exercise tolerance and muscle metabolism in elderly.
Study Type
Randomised controlled trial
Purpose
To assess magnesium orotate on exercise tolerance and muscle metabolism in elderly.
Dose
3000 mg/day magnesium orotate
Participants
30 elderly adults (65-80 years)
Duration
12 weeks
Results
Magnesium orotate improved exercise tolerance and showed trends towards higher muscle ATP content on MRS. VO2 max improved modestly but significantly.
How They Measured It
Exercise tolerance (treadmill), muscle ATP content (31P-MRS), VO2 max
Electrolyte & Metabolic
To evaluate magnesium orotate on intracellular magnesium levels and metabolic markers.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate magnesium orotate on intracellular magnesium levels and metabolic markers.
Dose
3000 mg/day magnesium orotate
Participants
50 adults with documented magnesium deficiency
Duration
8 weeks
Results
Magnesium orotate significantly increased both serum and intracellular magnesium levels. Orotate form showed superior intracellular penetration compared to historical data for other forms.
How They Measured It
Intracellular Mg (sublingual cell analysis), serum Mg, insulin resistance
To evaluate magnesium orotate on nocturnal leg cramps.
Study Type
Clinical study
Purpose
To evaluate magnesium orotate on nocturnal leg cramps.
Dose
1500 mg/day magnesium orotate
Participants
36 patients with frequent nocturnal leg cramps
Duration
6 weeks
Results
Magnesium orotate significantly reduced cramp frequency (72% reduction) and severity. Sleep quality improved concordantly.
How They Measured It
Cramp frequency, severity, duration, sleep quality
Mood & Mental Health
Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial.
Study Type
RCT
Purpose
Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial.
Dose
See study
Participants
120 participants
Duration
8 weeks
Results
demonstrated with an overall reduction in self-rated symptoms of anxiety and stress in the active treatment group compared with placebo.
How They Measured It
PubMed PMID: 39242786. Sci Rep
Frequently Asked Questions
Common questions about Magnesium Orotate research
There are currently 8 peer-reviewed studies on Magnesium Orotate (Magnesium orotate (C₁₀H₆MgN₄O₈)), involving 120 total participants. Research covers Cardiovascular health, Heart failure, Exercise capacity and 1 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (8 human studies), and reported outcomes.
Magnesium Orotate has been researched for: Cardiovascular health, Heart failure, Exercise capacity, Electrolyte balance. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 8 out of 8 studies are human trials. Human trials carry more weight in our evidence scoring system.
Similar Supplements
Other supplements researched for similar health goals
