Magnesium Malate
Research reviewed: Up until 03/2026
Magnesium Malate (Magnesium malate (C₄H₄MgO₅)) is a dietary supplement with 7 published peer-reviewed studies involving 202 participants, researched for Fibromyalgia & Muscle Pain, Energy & Exercise Performance, Bioavailability & Safety.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Fibromyalgia & Muscle Pain
StrongEnergy & Exercise Performance
ModerateBioavailability & Safety
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Fibromyalgia & Muscle Pain
To evaluate magnesium malate for pain and tenderness in fibromyalgia.
Study Type
Open-label clinical trial
Purpose
To evaluate magnesium malate for pain and tenderness in fibromyalgia.
Dose
300-600 mg elemental Mg as magnesium malate (1200-2400 mg total)
Participants
24 patients with fibromyalgia
Duration
8 weeks (2 months at low dose + 2 months at high dose)
Results
Magnesium malate significantly reduced tender point index and pain scores at both doses. Improvements were more pronounced at higher dose. Benefits diminished after washout.
How They Measured It
Tender point index (TPI), pain VAS, fatigue scores
To evaluate magnesium malate supplementation in fibromyalgia patients.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate magnesium malate supplementation in fibromyalgia patients.
Dose
Magnesium malate 1200 mg/day (150 mg elemental Mg + 600 mg malic acid)
Participants
40 female fibromyalgia patients
Duration
8 weeks
Results
Magnesium malate showed significant improvements in FIQ score and tender point count compared to placebo. Pain and fatigue also improved.
How They Measured It
FIQ score, tender point count, pain VAS, fatigue
To assess magnesium and malic acid combination on muscle pain and performance.
Study Type
Crossover clinical trial
Purpose
To assess magnesium and malic acid combination on muscle pain and performance.
Dose
Magnesium 300 mg + malic acid 1200 mg per day
Participants
30 patients with chronic myalgia
Duration
2 × 4 weeks crossover
Results
Magnesium malate significantly reduced muscle pain and improved grip strength during treatment periods. Benefits reversed during washout/placebo phases.
How They Measured It
Muscle pain intensity (VAS), grip strength, muscle endurance
Energy & Exercise Performance
To evaluate magnesium malate on exercise performance and recovery in athletes.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate magnesium malate on exercise performance and recovery in athletes.
Dose
350 mg elemental Mg as magnesium malate
Participants
26 recreationally trained adults
Duration
4 weeks supplementation + exercise protocol
Results
Magnesium malate improved peak torque during repeated exercise bouts and reduced post-exercise creatine kinase elevation, suggesting enhanced recovery.
How They Measured It
Peak torque, muscle soreness, creatine kinase, lactate
To evaluate magnesium malate on fatigue and energy levels in CFS patients.
Study Type
Randomised controlled trial
Purpose
To evaluate magnesium malate on fatigue and energy levels in CFS patients.
Dose
Magnesium malate 1200 mg/day
Participants
20 patients with chronic fatigue syndrome
Duration
8 weeks
Results
Magnesium malate significantly improved fatigue severity scores and self-reported energy levels. Serum magnesium levels normalized.
How They Measured It
Fatigue Severity Scale, energy level VAS, serum magnesium and malate
Bioavailability & Safety
To compare bioavailability of magnesium malate vs magnesium oxide and magnesium citrate.
Study Type
Randomised, crossover bioavailability study
Purpose
To compare bioavailability of magnesium malate vs magnesium oxide and magnesium citrate.
Dose
300 mg elemental Mg from each form
Participants
16 healthy volunteers
Duration
Single-dose crossover (3 visits)
Results
Magnesium malate showed significantly higher bioavailability (24-hour serum Mg AUC) than magnesium oxide and comparable to magnesium citrate. Better GI tolerability than citrate.
How They Measured It
Serum magnesium AUC, urinary magnesium excretion, GI tolerability
To evaluate long-term safety of magnesium malate supplementation.
Study Type
Open-label safety study
Purpose
To evaluate long-term safety of magnesium malate supplementation.
Dose
Magnesium malate 1200-2400 mg/day
Participants
46 adults with fibromyalgia
Duration
6 months
Results
Magnesium malate was well tolerated over 6 months with no significant adverse effects on renal function or cardiac conduction. Mild GI effects in 8% of participants.
How They Measured It
Serum magnesium, renal function, GI side effects, cardiac monitoring
Frequently Asked Questions
Common questions about Magnesium Malate research
There are currently 7 peer-reviewed studies on Magnesium Malate (Magnesium malate (C₄H₄MgO₅)), involving 202 total participants. Research covers Fibromyalgia, Energy production, Muscle pain and 1 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (7 human studies), and reported outcomes.
Magnesium Malate has been researched for: Fibromyalgia, Energy production, Muscle pain, Exercise performance. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 7 out of 7 studies are human trials. Human trials carry more weight in our evidence scoring system.
