Luteolin
Research reviewed: Up until 03/2026
Luteolin is a dietary supplement with 8 published peer-reviewed studies involving 269 participants, researched for Anti-inflammatory & Allergy, Neuroprotection & Autism Spectrum, Metabolic & Anti-inflammatory and 1 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Anti-inflammatory & Allergy
StrongNeuroprotection & Autism Spectrum
ModerateMetabolic & Anti-inflammatory
StrongAntioxidant & Cellular Protection
WeakResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Anti-inflammatory & Allergy
To evaluate luteolin-containing supplement on airway inflammation in mild asthma
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate luteolin-containing supplement on airway inflammation in mild asthma
Dose
100 mg/day luteolin-enriched supplement
Participants
45 adults with mild persistent asthma
Duration
12 weeks
Results
Significant reduction in FeNO (a marker of airway inflammation, p=0.03), improved FEV1, and better asthma control scores. CRP reduced. Anti-inflammatory effects confirmed.
How They Measured It
FeNO, spirometry, asthma control score, CRP
To assess luteolin supplement on allergic rhinitis symptoms
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To assess luteolin supplement on allergic rhinitis symptoms
Dose
100 mg/day luteolin-enriched celery extract
Participants
52 adults with seasonal allergic rhinitis
Duration
8 weeks
Results
Significant reduction in total nasal symptom score (p=0.02) and eosinophil count. IgE levels reduced by 14%. Quality of life improved vs placebo.
How They Measured It
Total nasal symptom score, IgE, eosinophil count
Neuroprotection & Autism Spectrum
To evaluate luteolin-containing supplement on inflammation and behaviour in autism spectrum disorder
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate luteolin-containing supplement on inflammation and behaviour in autism spectrum disorder
Dose
100 mg luteolin + quercetin + rutin per day
Participants
40 children with autism spectrum disorder
Duration
26 weeks
Results
Significant improvement in ABC-community scores (irritability, hyperactivity, social withdrawal) vs placebo (p<0.01). Inflammatory markers including IL-6 and TNF-alpha reduced.
How They Measured It
ABC-community scale, inflammatory biomarkers, mast cell activation
To assess the effect of luteolin formulation on cognitive function in children with ASD
Study Type
Open-label pilot study
Purpose
To assess the effect of luteolin formulation on cognitive function in children with ASD
Dose
400 mg/day luteolin in olive oil
Participants
37 children with high-functioning autism
Duration
26 weeks
Results
Significant improvements in cognitive measures, attention, and social responsiveness. CGI improved in 62% of participants. Anti-neuroinflammatory effects proposed.
How They Measured It
Neuropsychological battery, CGI, clinician global assessment
Metabolic & Anti-inflammatory
To evaluate luteolin on inflammatory markers and metabolic parameters
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate luteolin on inflammatory markers and metabolic parameters
Dose
80 mg/day luteolin
Participants
50 overweight adults with metabolic syndrome
Duration
12 weeks
Results
Significant reductions in CRP (24%), IL-6 (19%), and TNF-alpha (17%) vs placebo. HOMA-IR improved by 15%. Fasting glucose reduced.
How They Measured It
CRP, IL-6, TNF-alpha, fasting glucose, HOMA-IR
To assess luteolin on lipid profile and cardiovascular markers
Study Type
Randomised, placebo-controlled
Purpose
To assess luteolin on lipid profile and cardiovascular markers
Dose
100 mg/day luteolin-enriched supplement
Participants
45 adults with mild hyperlipidaemia
Duration
8 weeks
Results
Significant reductions in total cholesterol (8%), LDL (11%), and triglycerides (13%). HDL increased by 6%. Cardiovascular risk markers improved.
How They Measured It
Total cholesterol, LDL, HDL, triglycerides, ApoB
Antioxidant & Cellular Protection
To investigate luteolin anti-tumour and antioxidant mechanisms
Study Type
In vitro and mechanistic study
Purpose
To investigate luteolin anti-tumour and antioxidant mechanisms
Dose
Various concentrations
Participants
Multiple cancer cell lines
Duration
Various
Results
Luteolin demonstrated potent anti-proliferative effects, NF-kB inhibition, and induction of apoptosis across multiple cancer cell lines. High antioxidant capacity (ORAC). Translational interest high.
How They Measured It
Cancer cell proliferation, NF-kB inhibition, ORAC, SOD
To review human evidence for luteolin supplementation effects
Study Type
Systematic review
Purpose
To review human evidence for luteolin supplementation effects
Dose
Various
Participants
Systematic review
Duration
Various
Results
Human evidence supports anti-inflammatory, anti-allergy, and neuroprotective effects. ASD results promising. Metabolic benefits emerging. Bioavailability remains a challenge. More RCTs needed.
How They Measured It
Systematic review of clinical trials
Frequently Asked Questions
Common questions about Luteolin research
There are currently 8 peer-reviewed studies on Luteolin (Luteolin), involving 269 total participants. Research covers Anti-inflammatory, Neuroprotection, Antioxidant status and 2 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (6 human studies), and reported outcomes.
Luteolin has been researched for: Anti-inflammatory, Neuroprotection, Antioxidant status, Allergy & immune, Metabolic health. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 6 out of 8 studies are human trials. Human trials carry more weight in our evidence scoring system.
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