L-Serine
Research reviewed: Up until 03/2026
L-Serine (L-Serine (amino acid)) is a dietary supplement with 3 published peer-reviewed studies involving 180 participants, researched for Sleep Quality, Mental Health & Neurology.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Sleep Quality
ModerateMental Health & Neurology
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Sleep Quality
To evaluate effects of L-serine ingestion on human sleep quality
Study Type
Randomized, double-blind, placebo-controlled crossover
Purpose
To evaluate effects of L-serine ingestion on human sleep quality
Dose
L-serine 3 grams taken 30 minutes before bed
Participants
Healthy subjects dissatisfied with their sleep
Duration
Two 2-week periods (crossover design)
Results
L-serine significantly improved factors related to sleep initiation and maintenance (p=0.02, p=0.008). Subjective sleep quality significantly better with L-serine.
How They Measured It
Sleep initiation, sleep maintenance, subjective sleep quality, actigraphy
Mental Health & Neurology
To review effects of L-serine on human sleep and potential neurological applications
Study Type
Review article
Purpose
To review effects of L-serine on human sleep and potential neurological applications
Dose
Typical 2-3 grams/day
Participants
Various study populations
Duration
Various
Results
L-serine may influence GABA receptors, promoting better sleep and circadian rhythm regulation. Contributes to serotonin production for mood and stress regulation.
How They Measured It
Literature review of clinical and mechanistic studies
To review evidence for L-serine therapy in GRIN2B-related neurodevelopmental disorder
Study Type
Evidence review
Purpose
To review evidence for L-serine therapy in GRIN2B-related neurodevelopmental disorder
Dose
Various doses tested in trials
Participants
Patients with GRIN2B-related neurodevelopmental disorder
Duration
Various trial durations
Results
Preliminary evidence shows L-serine has potential effects on NMDA receptor modulation, improving neurological and psychiatric symptoms.
How They Measured It
Literature synthesis of clinical trial evidence
Frequently Asked Questions
Common questions about L-Serine research
There are currently 4 peer-reviewed studies on L-Serine (L-Serine (amino acid)), involving 180 total participants. Research covers Sleep quality, Mental health, Neurological health. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (3 human studies), and reported outcomes.
L-Serine has been researched for: Sleep quality, Mental health, Neurological health. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 3 out of 4 studies are human trials. Human trials carry more weight in our evidence scoring system.
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