Jatamansi
Research reviewed: Up until 03/2026
Jatamansi (Nardostachys jatamansi) is a dietary supplement with 8 published peer-reviewed studies involving 105 participants, researched for Sleep & Insomnia, Anxiety & Neuroprotection.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Sleep & Insomnia
ModerateAnxiety & Neuroprotection
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Sleep & Insomnia
Jatamansi vs Tagara (Valeriana wallichii) in primary insomnia
Study Type
Comparative clinical trial
Purpose
Jatamansi vs Tagara (Valeriana wallichii) in primary insomnia
Dose
500mg powder twice daily
Participants
60 primary insomnia patients
Duration
4 weeks
Results
Both significantly improved insomnia scores. Jatamansi showed comparable efficacy to Valerian. Both reduced sleep latency and improved sleep quality and duration.
How They Measured It
Insomnia Severity Index, PSQI, sleep diary
CNS depressant and hypnotic activity of Jatamansi rhizome
Study Type
Preclinical pharmacological study
Purpose
CNS depressant and hypnotic activity of Jatamansi rhizome
Dose
200-400mg/kg rhizome powder
Participants
Animal pharmacological study
Duration
Acute and sub-acute
Results
Significantly increased sleep duration; reduced locomotor activity without affecting muscle coordination. CNS depressant activity via GABA-A ergic mechanisms confirmed.
How They Measured It
Phenobarbitone sleep potentiation, locomotor activity, muscle relaxation
Anxiety & Neuroprotection
Anxiolytic mechanism of N. jatamansi via GABA-benzodiazepine pathway
Study Type
Mechanistic pharmacological study
Purpose
Anxiolytic mechanism of N. jatamansi via GABA-benzodiazepine pathway
Dose
200mg/kg ethanolic extract
Participants
Animal model
Duration
Acute
Results
Significant anxiolytic activity reversed by flumazenil, confirming GABA-BZD receptor mediation. Biodistribution studies confirmed CNS penetration of active constituents.
How They Measured It
EPM, open field test, biodistribution of 99mTc-labelled extract
Anti-depression mechanism of N. jatamansi via systems pharmacology
Study Type
Network pharmacology study
Purpose
Anti-depression mechanism of N. jatamansi via systems pharmacology
Dose
Active compounds at varying concentrations
Participants
In silico and in vitro
Duration
N/A
Results
Nardosinone identified as key MAO inhibitor. Multi-target antidepressant mechanism involving serotonin, dopamine and norepinephrine pathways.
How They Measured It
HPLC-MS compound identification, network analysis, MAO-A/B inhibition
Antioxidant and AChE inhibitory activities of N. jatamansi
Study Type
Antioxidant and enzyme inhibition study
Purpose
Antioxidant and AChE inhibitory activities of N. jatamansi
Dose
Various extract concentrations
Participants
In vitro study
Duration
N/A
Results
Potent antioxidant activity and significant AChE inhibition relevant for cognitive impairment. Alpha-glucosidase inhibition supports potential anti-diabetic application.
How They Measured It
DPPH, FRAP, AChE inhibition, alpha-glucosidase inhibition
Ethnomedicinal uses and pharmacological activities of N. jatamansi
Study Type
Review
Purpose
Ethnomedicinal uses and pharmacological activities of N. jatamansi
Dose
Various
Participants
Review
Duration
Various
Results
Sedative, anxiolytic, antidepressant, antiepileptic, antioxidant, and neuroprotective activities. Active compounds include sesquiterpenes, iridoids, and nardosinone. CNS applications well-supported.
How They Measured It
Comprehensive literature review
Jatamansi combined therapy in anxiety disorder management
Study Type
Clinical Ayurvedic study
Purpose
Jatamansi combined therapy in anxiety disorder management
Dose
1g rhizome powder twice daily
Participants
45 anxiety disorder patients
Duration
8 weeks
Results
Significant reduction in anxiety scores. 78% reported improvement in sleep quality and stress tolerance. Well tolerated.
How They Measured It
Hamilton Anxiety Scale, subjective symptom questionnaire
Jatamansi aromatherapy targeting MAOA gene in sleep deprivation
Study Type
Sleep pharmacology study
Purpose
Jatamansi aromatherapy targeting MAOA gene in sleep deprivation
Dose
N. jatamansi essential oil inhalation
Participants
Animal and clinical correlation
Duration
4 weeks
Results
Targeting MAOA gene regulated cardiac neural remodelling and amino acid metabolism to alleviate sleep deprivation-induced myocardial injury.
How They Measured It
Sleep quality, cardiac neural remodelling, amino acid metabolism
Frequently Asked Questions
Common questions about Jatamansi research
There are currently 8 peer-reviewed studies on Jatamansi (Nardostachys jatamansi), involving 105 total participants. Research covers Sleep quality & insomnia, Anxiety & stress reduction, Neuroprotection and 1 more areas. The overall evidence strength is rated as Moderate.
The evidence is currently rated as "Moderate Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (2 human studies), and reported outcomes.
Jatamansi has been researched for: Sleep quality & insomnia, Anxiety & stress reduction, Neuroprotection, Depression. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 2 out of 8 studies are human trials. Human trials carry more weight in our evidence scoring system.
