Hordenine
Research reviewed: 2013โ2019
Hordenine (N,N-Dimethyltyramine) is a dietary supplement with 8 published peer-reviewed studies involving 84 participants, researched for Metabolism & Energy, Adrenergic & Norepinephrine Effects, Mental Focus & Cognitive Effects.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Metabolism & Energy
ModerateAdrenergic & Norepinephrine Effects
ModerateMental Focus & Cognitive Effects
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Metabolism & Energy
Characterise hordenine MAO inhibitory activity and dopamine transporter interactions
Study Type
In Vitro Mechanistic Study
Purpose
Characterise hordenine MAO inhibitory activity and dopamine transporter interactions
Dose
Various concentrations
Participants
0
Duration
N/A
Results
Hordenine inhibits MAO-B preferentially and dopamine transporter; prolongs catecholamine availability
How They Measured It
MAO-A and MAO-B inhibition assays, transporter binding
Assess bioavailability and metabolism of hordenine after oral ingestion
Study Type
Pharmacokinetic Study
Purpose
Assess bioavailability and metabolism of hordenine after oral ingestion
Dose
4 mg from barley extract
Participants
8
Duration
Acute (12-hour)
Results
Hordenine absorbed with peak plasma at 1.5 hours; detectable up to 8 hours; moderate bioavailability
How They Measured It
Plasma and urinary hordenine via LC-MS/MS
Evaluate hordenine-containing pre-workout on energy and metabolic rate
Study Type
Randomised Controlled Trial
Purpose
Evaluate hordenine-containing pre-workout on energy and metabolic rate
Dose
Hordenine 50 mg in multi-ingredient formula
Participants
40
Duration
4 weeks
Results
Significant increase in RMR (+4.7%) and energy; difficulty isolating hordenine contribution from caffeine
How They Measured It
RMR via indirect calorimetry, VAS energy
Adrenergic & Norepinephrine Effects
Characterise hordenine adrenergic receptor binding profile
Study Type
In Vitro Receptor Study
Purpose
Characterise hordenine adrenergic receptor binding profile
Dose
Various concentrations
Participants
0
Duration
N/A
Results
Hordenine shows partial agonism at beta-2 adrenergic receptors; weaker than synephrine but dose-dependent
How They Measured It
Receptor binding assays; cAMP and calcium flux measurements
Assess norepinephrine reuptake inhibition by hordenine
Study Type
Animal Study (Rat)
Purpose
Assess norepinephrine reuptake inhibition by hordenine
Dose
10 mg/kg
Participants
20
Duration
Acute
Results
Hordenine increased extracellular norepinephrine by 35%; mild cardiovascular stimulation; no seizure activity
How They Measured It
Microdialysis; plasma catecholamine measurement
Evaluate hordenine dopamine transporter inhibition as cognitive mechanism
Study Type
In Vitro Mechanistic Study
Purpose
Evaluate hordenine dopamine transporter inhibition as cognitive mechanism
Dose
Various concentrations
Participants
0
Duration
N/A
Results
IC50 for dopamine transporter inhibition ~100 ยตM; mild dopaminergic activity at high concentrations
How They Measured It
Radioligand binding assays; dopamine uptake inhibition
Mental Focus & Cognitive Effects
Assess subjective focus and alertness after hordenine supplementation
Study Type
Open-Label Pilot Study
Purpose
Assess subjective focus and alertness after hordenine supplementation
Dose
25โ50 mg/day
Participants
16
Duration
4 weeks
Results
Significant improvement in self-rated focus and alertness; modest reduction in reaction time; no adverse effects
How They Measured It
VAS for focus, alertness, energy; reaction time
Review hordenine CNS and peripheral pharmacological effects
Study Type
Pharmacological Review
Purpose
Review hordenine CNS and peripheral pharmacological effects
Dose
N/A
Participants
0
Duration
N/A
Results
Hordenine demonstrates mild adrenomimetic, MAO-inhibitory, and dopaminergic activity; human clinical data sparse
How They Measured It
Narrative review of in vitro, animal, and human data
Frequently Asked Questions
Common questions about Hordenine research
There are currently 8 peer-reviewed studies on Hordenine (N,N-Dimethyltyramine), involving 84 total participants. Research covers Metabolism, Energy, Mental Focus and 1 more areas. The overall evidence strength is rated as Moderate.
The evidence is currently rated as "Moderate Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (8 human studies), and reported outcomes.
Hordenine has been researched for: Metabolism, Energy, Mental Focus, Adrenergic Effects. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 8 out of 8 studies are human trials. Human trials carry more weight in our evidence scoring system.
