Guduchi
Research reviewed: Up until 03/2026
Guduchi (Tinospora cordifolia (Giloy)) is a dietary supplement with 10 published peer-reviewed studies involving 301 participants, researched for Immune Function & Clinical Applications, Diabetes & Liver Health.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Immune Function & Clinical Applications
StrongDiabetes & Liver Health
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Immune Function & Clinical Applications
Medicinal applications and immunomodulatory effects of Tinospora cordifolia
Study Type
Comprehensive pharmacological review
Purpose
Medicinal applications and immunomodulatory effects of Tinospora cordifolia
Dose
Various
Participants
Review
Duration
Various
Results
Anti-oxidant, anti-hyperglycaemic, hepatoprotective, cardiovascular protective, neuroprotective, anti-anxiety, adaptogenic, antimicrobial activities. Immunomodulation via macrophage activation and cytokine regulation.
How They Measured It
Systematic literature review of pharmacological and clinical studies
Immunomodulatory effects of T. cordifolia in HIV-positive patients
Study Type
Clinical study
Purpose
Immunomodulatory effects of T. cordifolia in HIV-positive patients
Dose
300mg extract 3x/day
Participants
68 HIV-positive patients
Duration
6 months
Results
Significant improvements in CD4+ counts and quality of life. Immunomodulatory classification objectively supported by immune marker improvements.
How They Measured It
CD4+ T cell counts, immune markers, quality of life
Guduchi immunity in cancer patients receiving chemotherapy
Study Type
Clinical study
Purpose
Guduchi immunity in cancer patients receiving chemotherapy
Dose
1g/day T. cordifolia tablet
Participants
48 cancer chemotherapy patients
Duration
3 months
Results
Reduced chemotherapy-related adverse effects and maintained white blood cell counts. Immunoprotective effects in myelosuppressed patients confirmed.
How They Measured It
Blood cell counts, quality of life, adverse events
Guduchi for allergic rhinitis symptoms
Study Type
RCT
Purpose
Guduchi for allergic rhinitis symptoms
Dose
500mg extract twice daily
Participants
75 allergic rhinitis patients
Duration
8 weeks
Results
Significantly reduced nasal symptoms, total IgE, and eosinophil counts vs placebo. Th1/Th2 balance modulation mechanism proposed.
How They Measured It
Nasal symptom scores, total IgE, eosinophil count
Giloy in mild-moderate COVID-19 management
Study Type
COVID-19 clinical study
Purpose
Giloy in mild-moderate COVID-19 management
Dose
500mg twice daily
Participants
60 COVID-19 patients
Duration
2 weeks
Results
Significantly reduced inflammatory markers and recovery time. Improvements in fever, cough, and fatigue versus standard care alone.
How They Measured It
Recovery time, symptom resolution, CRP, IL-6
Diabetes & Liver Health
Validate antidiabetic claims of T. cordifolia
Study Type
Pharmacological review
Purpose
Validate antidiabetic claims of T. cordifolia
Dose
Various
Participants
Review
Duration
Various
Results
Multiple studies confirm antidiabetic activity through alpha-glucosidase inhibition, insulin secretion enhancement, and oxidative stress reduction. Clinical trials show meaningful glucose and HbA1c reductions.
How They Measured It
Critical review of clinical and experimental studies
Multifarious pharmacological paradigms of T. cordifolia
Study Type
Comprehensive pharmacological review
Purpose
Multifarious pharmacological paradigms of T. cordifolia
Dose
Various
Participants
Review
Duration
Various
Results
Anti-diabetic, antipyretic, anti-arthritic, antioxidant, anti-allergic, hepatoprotective, immunomodulatory. Berberine, tinosporin, and jatrorrhizine identified as key bioactives.
How They Measured It
Review of published literature
Validate traditional Guduchi pharmacology through experimental and clinical data
Study Type
Validation review
Purpose
Validate traditional Guduchi pharmacology through experimental and clinical data
Dose
Various
Participants
Multiple studies reviewed
Duration
Various
Results
Multi-system pharmacological activity confirmed, supporting Rasayana (rejuvenative) classification. Experimental and clinical validation of antidiabetic, immunomodulatory, and hepatoprotective properties.
How They Measured It
Literature compilation of experimental and clinical data
Antibacterial efficacy of T. cordifolia against AMR clinical isolates
Study Type
Antibacterial clinical study
Purpose
Antibacterial efficacy of T. cordifolia against AMR clinical isolates
Dose
Various extract concentrations
Participants
Clinical microbiology study
Duration
N/A
Results
Significant antibacterial activity against MRSA, E. coli, and Pseudomonas aeruginosa. Supports role in combating antimicrobial resistance as adjunct treatment.
How They Measured It
MIC determination, disk diffusion against clinical isolates
Hepatoprotective effects of Guduchi in liver disease patients
Study Type
Hepatoprotective clinical study
Purpose
Hepatoprotective effects of Guduchi in liver disease patients
Dose
400mg extract twice daily
Participants
50 elevated liver enzyme patients
Duration
12 weeks
Results
Significant reductions in ALT, AST, ALP, and total bilirubin. Improvements in albumin levels. Safe and effective hepatoprotective activity confirmed.
How They Measured It
Liver function tests (ALT, AST, ALP), bilirubin, albumin
Frequently Asked Questions
Common questions about Guduchi research
There are currently 10 peer-reviewed studies on Guduchi (Tinospora cordifolia (Giloy)), involving 301 total participants. Research covers Immune modulation, Blood sugar & diabetes, Liver protection and 1 more areas. The overall evidence strength is rated as Moderate.
The evidence is currently rated as "Moderate Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (5 human studies), and reported outcomes.
Guduchi has been researched for: Immune modulation, Blood sugar & diabetes, Liver protection, Anti-inflammatory & antioxidant. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 5 out of 10 studies are human trials. Human trials carry more weight in our evidence scoring system.
