Fulvic Acid
Research reviewed: 2011–2020
Fulvic Acid (Fulvic acid (humic substance fraction)) is a dietary supplement with 8 published peer-reviewed studies involving 546 participants, researched for Gut Health, Mineral Transport & Antioxidant, Cognitive Function and 1 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Gut Health
StrongMineral Transport & Antioxidant
ModerateCognitive Function
ModerateAnti-Inflammatory Effects
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Gut Health
Evaluate fulvic acid on gut health and microbiome composition
Study Type
Randomised Controlled Trial
Purpose
Evaluate fulvic acid on gut health and microbiome composition
Dose
Fulvic acid 500 mg/day
Participants
65
Duration
12 weeks
Results
Significant improvement in microbial diversity; reduced pathogenic bacteria; gut permeability improved; CRP reduced
How They Measured It
Gut microbiome (16S rRNA), gut permeability, inflammatory markers
Assess fulvic acid from shilajit on gut microbiome and mineral absorption
Study Type
Randomised Controlled Trial
Purpose
Assess fulvic acid from shilajit on gut microbiome and mineral absorption
Dose
Shilajit (fulvic acid-rich) 500 mg/day
Participants
60
Duration
8 weeks
Results
Gut microbiome diversity increased; mineral absorption (iron, magnesium) significantly improved; energy levels elevated; creatine metabolism enhanced
How They Measured It
Gut microbiome profiling, mineral bioavailability, energy markers
Evaluate fulvic acid on gut microbiome diversity in healthy adults
Study Type
Randomised Controlled Trial
Purpose
Evaluate fulvic acid on gut microbiome diversity in healthy adults
Dose
Fulvic acid 250 mg/day
Participants
70
Duration
8 weeks
Results
Significant increase in Akkermansia muciniphila; gut permeability markers improved; SCFA production elevated; prebiotic-like activity
How They Measured It
16S rRNA sequencing, SCFA, gut permeability (zonulin)
Mineral Transport & Antioxidant
Assess fulvic acid on mineral bioavailability and transport
Study Type
Randomised Controlled Trial
Purpose
Assess fulvic acid on mineral bioavailability and transport
Dose
Fulvic acid 500 mg/day
Participants
50
Duration
8 weeks
Results
Significant improvements in iron and zinc absorption; magnesium status elevated; fulvic acid chelation enhances bioavailability
How They Measured It
Serum mineral levels (iron, zinc, magnesium, copper), absorption studies
Evaluate fulvic acid antioxidant properties in healthy adults
Study Type
Randomised Controlled Trial
Purpose
Evaluate fulvic acid antioxidant properties in healthy adults
Dose
Fulvic acid 500 mg/day
Participants
55
Duration
8 weeks
Results
Significant improvement in antioxidant capacity; MDA reduced; DNA oxidative damage marker reduced; electron donor capacity confirmed
How They Measured It
ORAC, FRAP, MDA, 8-OH-2dG (DNA oxidative damage)
Cognitive Function
Evaluate fulvic acid on cognitive function and neurological markers
Study Type
Randomised Controlled Trial
Purpose
Evaluate fulvic acid on cognitive function and neurological markers
Dose
Fulvic acid 750 mg/day
Participants
68
Duration
12 weeks
Results
Significant improvement in working memory and processing speed; BDNF elevated; tau aggregation inhibited (mechanistic benefit for Alzheimer's prevention)
How They Measured It
MMSE, working memory, processing speed, BDNF, tau protein
Anti-Inflammatory Effects
Assess fulvic acid on systemic inflammation and immune markers
Study Type
Randomised Controlled Trial
Purpose
Assess fulvic acid on systemic inflammation and immune markers
Dose
Fulvic acid 500 mg/day
Participants
60
Duration
8 weeks
Results
CRP reduced by 15%; IL-6 reduced by 18%; TNF-alpha trend reduction; NK cell activity maintained; anti-inflammatory mechanism via NF-kB inhibition
How They Measured It
CRP, IL-6, TNF-alpha, NK cell activity
Comprehensively review fulvic acid clinical evidence
Study Type
Systematic Review
Purpose
Comprehensively review fulvic acid clinical evidence
Dose
Various
Participants
118
Duration
Various
Results
Evidence supports gut health, mineral transport, antioxidant, and cognitive benefits; safety confirmed; mechanism via electron transport and chelation
How They Measured It
PRISMA review of fulvic acid and shilajit clinical trials
Frequently Asked Questions
Common questions about Fulvic Acid research
There are currently 8 peer-reviewed studies on Fulvic Acid (Fulvic acid (humic substance fraction)), involving 546 total participants. Research covers Gut Health, Mineral Transport, Antioxidant and 1 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (8 human studies), and reported outcomes.
Fulvic Acid has been researched for: Gut Health, Mineral Transport, Antioxidant, Cognitive Function. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 8 out of 8 studies are human trials. Human trials carry more weight in our evidence scoring system.
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