DMAE
Research reviewed: Up until 03/2026
DMAE (Dimethylaminoethanol) is a dietary supplement with 3 published peer-reviewed studies involving 285 participants, researched for Skin Health & Anti-Aging, Mood & Brain Function, Cognitive Enhancement.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Skin Health & Anti-Aging
ModerateMood & Brain Function
ModerateCognitive Enhancement
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Skin Health & Anti-Aging
To evaluate the safety and efficacy of DMAE facial gel in mitigating signs of skin aging
Study Type
Randomized, clinical trial
Purpose
To evaluate the safety and efficacy of DMAE facial gel in mitigating signs of skin aging
Dose
3% DMAE facial gel applied daily
Participants
Healthy volunteers with aging skin signs
Duration
16 weeks
Results
3% DMAE gel was safe and efficacious in mitigating forehead lines and periorbital fine wrinkles, and improved overall appearance of aging skin (p < 0.05).
How They Measured It
Forehead line reduction, periorbital fine wrinkles, skin appearance scores
Mood & Brain Function
To evaluate efficacy of DMAE-containing vitamin-mineral combination on EEG patterns and mood
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To evaluate efficacy of DMAE-containing vitamin-mineral combination on EEG patterns and mood
Dose
DMAE in vitamin-mineral combination
Participants
Healthy volunteers
Duration
12 weeks
Results
Active drug group developed significantly less theta and alpha1 power in sensomotoric cortex areas. Mood profile analysis revealed better mood for DMAE group.
How They Measured It
EEG power spectral analysis, mood profile scores
Cognitive Enhancement
To review evidence for DMAE as a nootropic agent for cognitive enhancement
Study Type
Literature review
Purpose
To review evidence for DMAE as a nootropic agent for cognitive enhancement
Dose
Various (typical 320-2000 mg/day)
Participants
Various study populations
Duration
Various
Results
While DMAE is widely marketed as a memory enhancer, clinical studies supporting cognitive enhancement are limited. Research for Alzheimer's has largely yielded negative results.
How They Measured It
Literature synthesis of clinical studies
Frequently Asked Questions
Common questions about DMAE research
There are currently 5 peer-reviewed studies on DMAE (Dimethylaminoethanol), involving 285 total participants. Research covers Cognition, Mood, Skin health. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (3 human studies), and reported outcomes.
DMAE has been researched for: Cognition, Mood, Skin health. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 3 out of 5 studies are human trials. Human trials carry more weight in our evidence scoring system.
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