Dihydroberberine
Research reviewed: Up until 03/2026
Dihydroberberine (Dihydroberberine (DHB)) is a dietary supplement with 2 published peer-reviewed studies involving 185 participants, researched for Metabolic Health, Blood Sugar Control.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Metabolic Health
ModerateBlood Sugar Control
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Metabolic Health
To compare absorption kinetics of berberine vs dihydroberberine and their effects on blood glucose
Study Type
Randomized, double-blind, placebo-controlled crossover
Purpose
To compare absorption kinetics of berberine vs dihydroberberine and their effects on blood glucose
Dose
100-200 mg dihydroberberine vs 500 mg berberine
Participants
Healthy male volunteers
Duration
Single dose crossover design
Results
100-200 mg dihydroberberine showed superior bioavailability compared to 500 mg berberine with significantly higher plasma berberine AUC.
How They Measured It
Plasma berberine AUC, glucose and insulin levels
Blood Sugar Control
To evaluate efficacy and safety of berberine on metabolic syndrome components
Study Type
Systematic review and meta-analysis
Purpose
To evaluate efficacy and safety of berberine on metabolic syndrome components
Dose
Various berberine doses (typically 500 mg-1500 mg/day)
Participants
Meta-analysis of multiple RCTs
Duration
Various (8-24 weeks typical)
Results
Berberine significantly reduces triglycerides, fasting plasma glucose, and waist circumference among metabolic syndrome components.
How They Measured It
Meta-analysis of RCT data on glucose, lipids, and waist circumference
Frequently Asked Questions
Common questions about Dihydroberberine research
There are currently 4 peer-reviewed studies on Dihydroberberine (Dihydroberberine (DHB)), involving 185 total participants. Research covers Blood sugar control, Metabolic health, Cardiovascular health. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (2 human studies), and reported outcomes.
Dihydroberberine has been researched for: Blood sugar control, Metabolic health, Cardiovascular health. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 2 out of 4 studies are human trials. Human trials carry more weight in our evidence scoring system.
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