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Amorphous Hydrated Silicon Dioxide

Diatomaceous Earth

Research reviewed: Up until 03/2026

Diatomaceous Earth (Amorphous Hydrated Silicon Dioxide) is a dietary supplement with 3 published peer-reviewed studies involving 84 participants, researched for Bone & Connective Tissue Health, Clinical trials.

3
Studies
84
Participants
2007–2025
Research Span

Evidence at a Glance

Strength is scored by study design, sample size, study type, and outcomes

Overall: Moderate Evidence

Bone & Connective Tissue Health

Moderate
2 studies 1 of 2 positive 84 participants

Clinical trials

Weak
1 study 0 of 1 positive 18 participants

Research Visualised

Visual breakdown of the clinical data.

Study Quality Breakdown

What types of studies were conducted

3/3
Randomised
2/3
Double-Blind
3/3
Placebo-Controlled

Participants Per Study

Larger samples = more reliable results

Study 1 (2007)
36
Study 2 (2007)
48
Study 3 (2025)
18

Research Timeline

When the studies were published

2
2007
1
2025

All Studies

Detailed breakdown of each trial. Click to expand.

Bone & Connective Tissue Health

1

To assess dietary silicon from diatomaceous earth on bone mineral density.

2007 36 participants 6 months Food-grade diatomaceous earth 250mg silicon daily
Human Study RCT Double-Blind Placebo Mixed

Study Type

Randomised, double-blind, placebo-controlled

Purpose

To assess dietary silicon from diatomaceous earth on bone mineral density.

Dose

Food-grade diatomaceous earth 250mg silicon daily

Participants

36 postmenopausal women

Duration

6 months

Results

Silicon supplementation from diatomaceous earth modestly improved bone turnover markers and tended to increase BMD. Silicon's role in collagen cross-linking in bone matrix supported.

How They Measured It

BMD (DXA), bone turnover markers, serum silicon levels

Read full study
2

To assess oral silicon supplementation on hair and nail strength.

2007 48 participants 9 months Choline-stabilised orthosilicic acid 10mg daily
Human Study RCT Double-Blind Placebo Positive

Study Type

Randomised, double-blind, placebo-controlled

Purpose

To assess oral silicon supplementation on hair and nail strength.

Dose

Choline-stabilised orthosilicic acid 10mg daily

Participants

48 women with brittle hair and nails

Duration

9 months

Results

Silicon supplementation significantly improved hair tensile strength and nail brittleness scores. Hair keratin content increased. Confirmed role of silicon in hair and nail structural integrity.

How They Measured It

Hair tensile strength, nail brittleness score, hair keratin content

Read full study

Clinical trials

3

To assess postprandial metabolism and silicon bioavailability from diatomaceous earth added to a reduced-fat meat product in adults.

2025 18 participants Single postprandial session (4 hours) Reduced-fat or standard pâté with added diatomaceous earth s...
Human Study RCT Placebo Mixed

Study Type

Randomized, four-way crossover, placebo-controlled

Purpose

To assess postprandial metabolism and silicon bioavailability from diatomaceous earth added to a reduced-fat meat product in adults.

Dose

Reduced-fat or standard pâté with added diatomaceous earth silicon; 4-way crossover

Participants

18 adults (mean age 58 years, 68% women)

Duration

Single postprandial session (4 hours)

Results

Silicon from diatomaceous earth was unabsorbed and had no effect on normal postprandial metabolism. Authors concluded it should not be used as a bioactive ingredient in functional foods.

How They Measured It

Serum silicon, triglycerides, glucose, and insulin over 4h postprandially

Read full study

Frequently Asked Questions

Common questions about Diatomaceous Earth research

What does the research say about Diatomaceous Earth?

There are currently 3 peer-reviewed studies on Diatomaceous Earth (Amorphous Hydrated Silicon Dioxide), involving 84 total participants. Research covers Detoxification, Bone health, Digestive health and 1 more areas. The overall evidence strength is rated as Moderate.

How strong is the evidence for Diatomaceous Earth?

The evidence is currently rated as "Moderate Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (3 human studies), and reported outcomes.

What health goals has Diatomaceous Earth been studied for?

Diatomaceous Earth has been researched for: Detoxification, Bone health, Digestive health, Hair & nail strength. Each area has its own body of evidence which you can explore in the study breakdowns above.

Are the studies on Diatomaceous Earth based on human trials?

Yes, 3 out of 3 studies are human trials. Human trials carry more weight in our evidence scoring system.