Creatinol O-Phosphate
Research reviewed: Up until 03/2026
Creatinol O-Phosphate is a dietary supplement with 7 published peer-reviewed studies involving 256 participants, researched for Cardiovascular Protection, Exercise Performance.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Cardiovascular Protection
StrongExercise Performance
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Cardiovascular Protection
To evaluate creatinol O-phosphate (COP) for cardioprotection during cardiac surgery
Study Type
Randomised controlled trial
Purpose
To evaluate creatinol O-phosphate (COP) for cardioprotection during cardiac surgery
Dose
30 mg/kg IV COP
Participants
80 patients undergoing cardiac surgery
Duration
Perioperative
Results
COP significantly reduced cardiac enzyme release (CK-MB, troponin) and ECG ischemia during cardiac surgery, indicating cardioprotective effect.
How They Measured It
Cardiac enzymes (CK-MB, troponin), ECG changes
To assess COP on cardiac protection in myocardial infarction
Study Type
Randomised controlled trial
Purpose
To assess COP on cardiac protection in myocardial infarction
Dose
60 mg/kg IV
Participants
64 acute MI patients
Duration
Acute hospitalization
Results
COP administration significantly reduced infarct size and improved left ventricular ejection fraction in acute MI patients vs control.
How They Measured It
Infarct size, LVEF, mortality
To investigate COP mechanisms in ischemic heart tissue
Study Type
Animal study
Purpose
To investigate COP mechanisms in ischemic heart tissue
Dose
30 mg/kg
Participants
Rat hearts (ex vivo and in vivo)
Duration
Acute
Results
COP significantly preserved mitochondrial function, maintained ATP levels, and reduced apoptosis in ischemic cardiac tissue via membrane stabilization.
How They Measured It
Mitochondrial function, ATP preservation, cell death markers
To evaluate COP on arrhythmia during cardiac stress
Study Type
Clinical study
Purpose
To evaluate COP on arrhythmia during cardiac stress
Dose
30 mg/kg IV
Participants
42 patients with ischemic cardiac disease
Duration
Acute
Results
COP significantly reduced arrhythmia frequency and severity during cardiac stress testing. Cardioprotective and antiarrhythmic effects confirmed.
How They Measured It
ECG, arrhythmia frequency and severity
Exercise Performance
To assess oral COP on exercise performance and muscle endurance
Study Type
Randomised double-blind trial
Purpose
To assess oral COP on exercise performance and muscle endurance
Dose
3-4 g/day oral COP
Participants
40 trained athletes
Duration
4 weeks
Results
Oral COP supplementation improved anaerobic threshold and muscle endurance, with reduced blood lactate accumulation during high-intensity exercise. PMID: 8418571
How They Measured It
Anaerobic threshold, muscle endurance, lactate levels
To evaluate COP on cardiovascular efficiency during high-intensity exercise
Study Type
Randomised controlled trial
Purpose
To evaluate COP on cardiovascular efficiency during high-intensity exercise
Dose
2 g/day COP
Participants
30 trained men
Duration
6 weeks
Results
COP supplementation improved cardiovascular efficiency during maximal exercise, reducing cardiac stress markers while maintaining performance output. PMID: 1576459
How They Measured It
Heart rate, VO2, cardiac output at maximal effort
To review creatinol O-phosphate pharmacology and therapeutic applications
Study Type
Review
Purpose
To review creatinol O-phosphate pharmacology and therapeutic applications
Dose
Various
Participants
N/A
Duration
N/A
Results
COP demonstrated cardioprotective effects via membrane stabilization and pH buffering in ischemic and exercise settings. Both cardiac protection and performance enhancement supported.
How They Measured It
Comprehensive literature review
Frequently Asked Questions
Common questions about Creatinol O-Phosphate research
There are currently 7 peer-reviewed studies on Creatinol O-Phosphate (Creatinol O-Phosphate), involving 256 total participants. Research covers Cardiovascular protection, Exercise performance, Cardioprotection. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (5 human studies, 1 animal study), and reported outcomes.
Creatinol O-Phosphate has been researched for: Cardiovascular protection, Exercise performance, Cardioprotection. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 5 out of 7 studies are human trials. The remaining 1 is an animal study. Human trials carry more weight in our evidence scoring system.
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