Citrus Bioflavonoids
Research reviewed: Up until 03/2026
Citrus Bioflavonoids (Citrus Flavonoids (hesperidin, diosmin, naringenin, and related polyphenols from Citrus spp.)) is a dietary supplement with 6 published peer-reviewed studies involving 200 participants, researched for Chronic Venous Insufficiency, Lymphoedema & Oedema, Antioxidant & Anti-inflammatory Activity.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Chronic Venous Insufficiency
StrongLymphoedema & Oedema
WeakAntioxidant & Anti-inflammatory Activity
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Chronic Venous Insufficiency
To evaluate the clinical efficacy of micronised purified flavonoid fraction (MPFF; 90% diosmin + 10% hesperidin) in venous oedema.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate the clinical efficacy of micronised purified flavonoid fraction (MPFF; 90% diosmin + 10% hesperidin) in venous oedema.
Dose
500 mg MPFF twice daily (1000 mg/day)
Participants
200 patients with chronic venous insufficiency
Duration
3 months
Results
MPFF significantly decreased limb oedema volume and improved symptom scores vs placebo. Capillary hyperpermeability decreased. QoL improved. Both venous tone and lymphatic drainage were enhanced.
How They Measured It
Limb volume (plethysmography), symptom scores, quality of life
To review the evidence for flavonoids including citrus bioflavonoids in chronic venous disease treatment.
Study Type
Systematic review
Purpose
To review the evidence for flavonoids including citrus bioflavonoids in chronic venous disease treatment.
Dose
Various flavonoid formulations
Participants
Systematic review
Duration
Various
Results
Strong evidence supports MPFF (diosmin/hesperidin) for CVI. Effects include venous tone improvement, capillary protection, anti-inflammatory activity, and lymphatic drainage enhancement.
How They Measured It
Symptom scores, oedema reduction, QoL across eligible trials
To review the therapeutic potential of flavonoids in chronic venous insufficiency.
Study Type
Narrative review
Purpose
To review the therapeutic potential of flavonoids in chronic venous insufficiency.
Dose
Various
Participants
Review
Duration
Various
Results
Citrus bioflavonoids improve venous tone, reduce venous pressure, inhibit leukocyte adhesion, and reduce capillary hyperpermeability. Clinical trials consistently show symptom relief (leg heaviness, swelling, cramps) in CVI patients.
How They Measured It
Clinical symptom improvement, venous haemodynamics, oedema, QoL
The Effect of Hesperidin and Diosmin Individually or in Combination on Metabolic Profile and Neuropathy among Diabetic Patients with Metabolic Syndrome: A Randomized Controlled Trial
Study Type
Randomised, double-blind, placebo-controlled
Purpose
The Effect of Hesperidin and Diosmin Individually or in Combination on Metabolic Profile and Neuropathy among Diabetic Patients with Metabolic Syndrome: A Randomized Controlled Trial
Dose
As per study protocol
Participants
See full study
Duration
See full study
Results
Statistically significant findings reported — see full study for complete results.
How They Measured It
See full study for endpoints and measurement methods
Lymphoedema & Oedema
To investigate the anti-oedemic mechanisms of bioflavonoids in experimental models and clinical settings.
Study Type
Mechanistic review
Purpose
To investigate the anti-oedemic mechanisms of bioflavonoids in experimental models and clinical settings.
Dose
Various bioflavonoid preparations
Participants
Review
Duration
Various
Results
Citrus bioflavonoids reduce microvascular permeability, increase lymphatic drainage, and decrease fluid accumulation in interstitial tissues. The diosmin/hesperidin combination (MPFF) demonstrated the most consistent anti-oedemic effects.
How They Measured It
Lymphatic flow, capillary pressure, interstitial oedema
Antioxidant & Anti-inflammatory Activity
To evaluate low-dose diosmin therapy on symptoms and QoL in patients with chronic venous disease.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate low-dose diosmin therapy on symptoms and QoL in patients with chronic venous disease.
Dose
600 mg/day diosmin (low-dose)
Participants
Patients with chronic venous disease
Duration
12 weeks
Results
Low-dose diosmin significantly improved QoL (CIVIQ-20) and symptom severity vs placebo. Anti-inflammatory effects evidenced by reductions in pro-inflammatory mediators (IL-6, TNF-α) and decreased vascular permeability.
How They Measured It
CIVIQ-20 quality of life questionnaire, symptom severity score
Frequently Asked Questions
Common questions about Citrus Bioflavonoids research
There are currently 6 peer-reviewed studies on Citrus Bioflavonoids (Citrus Flavonoids (hesperidin, diosmin, naringenin, and related polyphenols from Citrus spp.)), involving 200 total participants. Research covers Chronic venous insufficiency, Lymphoedema & oedema reduction, Capillary protection and 1 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (3 human studies), and reported outcomes.
Citrus Bioflavonoids has been researched for: Chronic venous insufficiency, Lymphoedema & oedema reduction, Capillary protection, Antioxidant & anti-inflammatory activity. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 3 out of 6 studies are human trials. Human trials carry more weight in our evidence scoring system.
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