Cissus Quadrangularis
Research reviewed: Up until 03/2026
Cissus Quadrangularis (Cissus quadrangularis L.) is a dietary supplement with 4 published peer-reviewed studies involving 412 participants, researched for Joint Health, Bone Health & Healing, Weight Loss.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Joint Health
ModerateBone Health & Healing
ModerateWeight Loss
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Joint Health
To evaluate effects of Cissus quadrangularis supplementation on joint pain in exercise-trained men
Study Type
Randomized controlled trial
Purpose
To evaluate effects of Cissus quadrangularis supplementation on joint pain in exercise-trained men
Dose
CQR-300 3200 mg/day
Participants
29 young, exercise-trained men
Duration
8 weeks
Results
Cissus quadrangularis supplementation significantly reduced joint pain in exercise-trained men compared to placebo.
How They Measured It
Joint pain scores, mobility assessment
Bone Health & Healing
To evaluate the effect of Cissus quadrangularis on delaying bone loss in postmenopausal women with osteopenia
Study Type
Randomized, placebo-controlled
Purpose
To evaluate the effect of Cissus quadrangularis on delaying bone loss in postmenopausal women with osteopenia
Dose
Cissus quadrangularis extract
Participants
Postmenopausal women with osteopenia
Duration
24 weeks
Results
Cissus quadrangularis showed promising effect on delaying bone loss in postmenopausal women, as indicated by slower bone remodeling process.
How They Measured It
Bone mineral density, bone remodeling markers
To evaluate effects of Cissus quadrangularis on bone-related biomarkers in humans
Study Type
Systematic review and meta-analysis
Purpose
To evaluate effects of Cissus quadrangularis on bone-related biomarkers in humans
Dose
Various doses
Participants
Meta-analysis of 7 studies with bone fracture, oral cavity bone disease, and metabolic bone disease patients
Duration
Various
Results
Meta-analysis found CQ intervention resulted in significant increase in serum parathyroid hormone levels compared to control.
How They Measured It
Meta-analysis of RCT data on bone biomarkers
Weight Loss
To evaluate Cissus quadrangularis supplementation on body weight and metabolic parameters in overweight/obese subjects
Study Type
Double-blind, randomized, placebo-controlled
Purpose
To evaluate Cissus quadrangularis supplementation on body weight and metabolic parameters in overweight/obese subjects
Dose
Cissus quadrangularis extract CQR-300 3200 mg/day
Participants
123 overweight and obese subjects
Duration
8 weeks
Results
Cissus quadrangularis significantly reduced bodyweight and central obesity, improved blood glucose, total cholesterol, and triglycerides.
How They Measured It
Body weight, fat mass, glucose, cholesterol, triglycerides
Frequently Asked Questions
Common questions about Cissus Quadrangularis research
There are currently 7 peer-reviewed studies on Cissus Quadrangularis (Cissus quadrangularis L.), involving 412 total participants. Research covers Joint health, Bone healing, Weight loss. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (4 human studies), and reported outcomes.
Cissus Quadrangularis has been researched for: Joint health, Bone healing, Weight loss. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 4 out of 7 studies are human trials. Human trials carry more weight in our evidence scoring system.
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