Celery Seed Extract
Research reviewed: Up until 03/2026
Celery Seed Extract (Apium graveolens (Celery)) is a dietary supplement with 10 published peer-reviewed studies involving 155 participants, researched for Blood Pressure Management.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Blood Pressure Management
StrongResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Blood Pressure Management
To assess the antihypertensive effects of celery seed extract in hypertensive patients.
Study Type
Randomised, triple-blind, placebo-controlled crossover
Purpose
To assess the antihypertensive effects of celery seed extract in hypertensive patients.
Dose
75 mg celery seed extract twice daily (standardised to 3-n-butylphthalide)
Participants
30 hypertensive adults
Duration
12 weeks per arm (crossover)
Results
Celery seed extract significantly reduced SBP by 8.2 mmHg and DBP by 5.6 mmHg vs placebo (p<0.05). No significant adverse effects. Liver and kidney function remained normal.
How They Measured It
Clinic SBP and DBP at 4, 8, and 12 weeks; safety labs
To evaluate the safety and biochemical efficacy of celery seed extract capsules in hypertensive patients.
Study Type
Randomised, triple-blind, placebo-controlled crossover
Purpose
To evaluate the safety and biochemical efficacy of celery seed extract capsules in hypertensive patients.
Dose
75 mg celery seed extract twice daily
Participants
35 hypertensive adults
Duration
12 weeks
Results
Celery seed extract was safe with no significant changes in liver or kidney function. Blood pressure significantly reduced (SBP −7.4 mmHg, DBP −4.9 mmHg vs placebo). Lipid profile showed modest improvements in TC and TG.
How They Measured It
Safety: liver/kidney function, haematology. Efficacy: blood pressure, lipids, glucose
To evaluate the effects of celery on blood pressure, glycaemic control, and lipid profile.
Study Type
Systematic review and meta-analysis
Purpose
To evaluate the effects of celery on blood pressure, glycaemic control, and lipid profile.
Dose
Various celery preparations (juice, extract, seed)
Participants
Meta-analysis of RCTs
Duration
Various
Results
Celery significantly reduced SBP and DBP in pooled analysis. Modest reductions in TC, TG, and fasting glucose also observed. Effects consistent across formulations, supporting 3-n-butylphthalide as key active compound.
How They Measured It
Pooled SBP, DBP, TC, TG, LDL-C, fasting glucose from RCTs
To investigate the antihypertensive effect of celery seed extracts in normotensive and hypertensive rat models.
Study Type
Preclinical study — in vivo rat model
Purpose
To investigate the antihypertensive effect of celery seed extracts in normotensive and hypertensive rat models.
Dose
Various celery seed extract doses administered orally
Participants
Wistar rat model
Duration
4 weeks chronic administration
Results
n-Butylphthalide fraction significantly reduced blood pressure in hypertensive rats without affecting normotensive animals. Calcium channel antagonism and ACE inhibition were proposed mechanisms. Supports dose-dependent antihypertensive effects.
How They Measured It
Direct arterial blood pressure measurement in DOCA-salt hypertensive rat model
To evaluate beneficial effects of celery seed extract on anxiety and depression in hypertensive patients.
Study Type
Randomised clinical trial
Purpose
To evaluate beneficial effects of celery seed extract on anxiety and depression in hypertensive patients.
Dose
75 mg celery seed extract twice daily
Participants
72 hypertensive adults
Duration
8 weeks
Results
Celery seed extract significantly reduced anxiety (HADS-A −4.2) and depression (HADS-D −3.1) vs placebo. Cortisol modestly reduced. Blood pressure improvements also maintained. Dual cardiovascular and mental health benefits.
How They Measured It
Hospital Anxiety and Depression Scale (HADS), blood pressure, cortisol levels
To summarise the therapeutic potential of Apium graveolens and its bioactive constituents for cardiovascular health.
Study Type
Narrative review
Purpose
To summarise the therapeutic potential of Apium graveolens and its bioactive constituents for cardiovascular health.
Dose
Various celery preparations
Participants
Multiple studies reviewed
Duration
Various
Results
Celery seed extract exhibits consistent antihypertensive, antioxidant, anti-inflammatory, and diuretic properties. Human clinical trials support meaningful blood pressure reductions (5–10 mmHg). Suitable for pre-hypertension and stage I hypertension management.
How They Measured It
Review of in vitro, animal, and clinical data on blood pressure, lipids, and inflammation
To elucidate the molecular mechanisms of 3-n-butylphthalide on vascular tone.
Study Type
In vitro / mechanistic study
Purpose
To elucidate the molecular mechanisms of 3-n-butylphthalide on vascular tone.
Dose
Various concentrations of 3-n-butylphthalide in vitro
Participants
In vitro and animal model
Duration
Various
Results
3-n-Butylphthalide caused dose-dependent relaxation of vascular smooth muscle via L-type calcium channel blockade and increased NO production. Mechanistically supports clinical blood pressure-lowering effects of celery seed extract.
How They Measured It
Vascular smooth muscle calcium channel studies, aortic ring relaxation assays
To assess celery extract on blood pressure in subjects with mild-to-moderate hypertension over 8 weeks.
Study Type
Randomised, placebo-controlled pilot trial
Purpose
To assess celery extract on blood pressure in subjects with mild-to-moderate hypertension over 8 weeks.
Dose
150 mg celery seed extract once daily
Participants
18 hypertensive adults
Duration
8 weeks
Results
Celery seed extract produced significant reductions in SBP and DBP vs placebo. Mean SBP reduction was −6.5 mmHg. No adverse effects on liver or kidney function. Consistent with 3-n-butylphthalide mediating vasodilatory effects.
How They Measured It
Home and clinic blood pressure readings; safety labs
Efficacy and Safety of Boswellia serrata and Apium graveolens L. Extract Against Knee Osteoarthritis and Cartilage Degeneration: A Randomized, Double-blind, Multicenter, Placebo-Controlled Clinical Trial
Study Type
Randomised, double-blind, placebo-controlled
Purpose
Efficacy and Safety of Boswellia serrata and Apium graveolens L. Extract Against Knee Osteoarthritis and Cartilage Degeneration: A Randomized, Double-blind, Multicenter, Placebo-Controlled Clinical Trial
Dose
As per study protocol
Participants
See full study
Duration
See full study
Results
Statistically significant findings reported — see full study for complete results.
How They Measured It
See full study for endpoints and measurement methods
Effectiveness of acupuncture and a cumin-based herbal formula on anthropometric indices of overweight patients: a randomized double-blind placebo-controlled clinical trial
Study Type
Randomised, double-blind, placebo-controlled
Purpose
Effectiveness of acupuncture and a cumin-based herbal formula on anthropometric indices of overweight patients: a randomized double-blind placebo-controlled clinical trial
Dose
As per study protocol
Participants
See full study
Duration
See full study
Results
Statistically significant findings reported — see full study for complete results.
How They Measured It
See full study for endpoints and measurement methods
Frequently Asked Questions
Common questions about Celery Seed Extract research
There are currently 10 peer-reviewed studies on Celery Seed Extract (Apium graveolens (Celery)), involving 155 total participants. Research covers Blood pressure management, Antihypertensive effects, Lipid profile support and 1 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (6 human studies), and reported outcomes.
Celery Seed Extract has been researched for: Blood pressure management, Antihypertensive effects, Lipid profile support, Anti-inflammatory activity. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 6 out of 10 studies are human trials. Human trials carry more weight in our evidence scoring system.
