Bergamot Polyphenols
Research reviewed: Up until 03/2026
Bergamot Polyphenols (Citrus bergamia Polyphenolic Fraction (BPF)) is a dietary supplement with 9 published peer-reviewed studies involving 671 participants, researched for Cholesterol & Cardiovascular, AMPK Mechanism & Antioxidant, Clinical trials.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Cholesterol & Cardiovascular
StrongAMPK Mechanism & Antioxidant
ModerateClinical trials
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Cholesterol & Cardiovascular
BPF for hypercholesterolaemia and cardiometabolic risk reduction
Study Type
RCT
Purpose
BPF for hypercholesterolaemia and cardiometabolic risk reduction
Dose
1000mg BPF daily
Participants
237 patients with mixed dyslipidaemia
Duration
30 days
Results
Significant reductions: total cholesterol 29.2%, LDL 37.5%, TG 31.8%; HDL increased 22.6%. FBS significantly reduced. Anti-atherogenic index improved.
How They Measured It
Total cholesterol, LDL, HDL, TG, FBS, CRP
BPF as add-on to statin therapy for improved lipid lowering
Study Type
Statin combination RCT
Purpose
BPF as add-on to statin therapy for improved lipid lowering
Dose
1000mg BPF + rosuvastatin 10mg
Participants
80 statin therapy patients
Duration
30 days
Results
Significantly greater LDL reductions than statin alone. Arterial stiffness and inflammatory markers improved in combination group. Supports BPF as statin adjunct.
How They Measured It
LDL-C, total cholesterol, arterial stiffness, inflammatory markers
BPF for non-alcoholic fatty liver disease management
Study Type
NAFLD clinical study
Purpose
BPF for non-alcoholic fatty liver disease management
Dose
600mg BPF twice daily
Participants
120 NAFLD patients
Duration
12 weeks
Results
Significantly reduced liver fat, ALT, and oxidative stress markers. HOMA-IR improved. Comprehensive metabolic and hepatic improvements confirmed.
How They Measured It
Hepatic steatosis index, liver enzymes, HOMA-IR, oxidative stress
AMPK Mechanism & Antioxidant
AMPK activation as mechanism of BPF cholesterol-lowering activity
Study Type
Mechanistic clinical study
Purpose
AMPK activation as mechanism of BPF cholesterol-lowering activity
Dose
1000mg BPF
Participants
Human clinical samples + cell line validation
Duration
30 days
Results
BPF activated AMPK in peripheral blood cells and modulated HMGCR activity. Novel statin-independent mechanism for cholesterol reduction identified.
How They Measured It
AMPK phosphorylation, HMGCR activity, LDL-receptor expression
BPF as alternative for statin-intolerant patients with hypercholesterolaemia
Study Type
Statin-intolerant patient trial
Purpose
BPF as alternative for statin-intolerant patients with hypercholesterolaemia
Dose
1000mg BPF daily
Participants
45 statin-intolerant patients
Duration
12 weeks
Results
Clinically meaningful lipid reductions without myopathy or liver enzyme elevation. Effective alternative for statin-intolerant patients confirmed.
How They Measured It
Lipid panel, tolerability, myopathy symptoms
BPF for glucose and lipid management in type 2 diabetes as add-on to metformin
Study Type
Type 2 diabetes adjunct study
Purpose
BPF for glucose and lipid management in type 2 diabetes as add-on to metformin
Dose
500mg BPF twice daily
Participants
60 type 2 diabetic patients
Duration
12 weeks
Results
Significant improvements in HbA1c, FBS, and lipid profiles. AMPK activation mechanism provides synergistic benefit with metformin.
How They Measured It
FBS, HbA1c, lipid profile, HOMA-IR
Cytoprotective and antioxidant effects of BPF at cellular level
Study Type
Antioxidant and cytoprotective study
Purpose
Cytoprotective and antioxidant effects of BPF at cellular level
Dose
Various BPF concentrations
Participants
In vitro cell studies
Duration
N/A
Results
Significant cytoprotection against oxidative stress. Mitochondrial membrane potential preserved. Antioxidant effects complement lipid-lowering activity.
How They Measured It
Oxidative stress markers, mitochondrial function, cell viability
Neuroprotective and cognitive effects of bergamot polyphenols in older adults
Study Type
Cognitive health pilot study
Purpose
Neuroprotective and cognitive effects of bergamot polyphenols in older adults
Dose
500mg BPF daily
Participants
35 older adults with mild cognitive concerns
Duration
12 weeks
Results
Significantly improved cognitive assessment scores and reduced oxidative stress. Polyphenols (neoeriocitrin, hesperidin) may protect against cognitive decline.
How They Measured It
Cognitive assessment, neuroprotective biomarkers, oxidative stress
Clinical trials
To investigate the effects of Bergamot Polyphenols in citrus bergamia and cynara cardunculus reduce serum uric acid in individuals with non-alcoholic fatty liver disease.
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Bergamot Polyphenols in citrus bergamia and cynara cardunculus reduce serum uric acid in individuals with non-alcoholic fatty liver disease.
Dose
300 mg/day
Participants
94 participants
Duration
6 weeks
Results
A nutraceutical containing bioactive components from bergamot and wild cardoon reduced serum uric acid during 6 weeks in adults with fatty liver. Future investigations are needed to evaluate the efficacy of this nutraceutical in the treatment of hyperuricaemia.
How They Measured It
See study for outcome measures
Frequently Asked Questions
Common questions about Bergamot Polyphenols research
There are currently 9 peer-reviewed studies on Bergamot Polyphenols (Citrus bergamia Polyphenolic Fraction (BPF)), involving 671 total participants. Research covers Cholesterol & Cardiovascular, AMPK Mechanism & Antioxidant, Clinical trials. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (8 human studies), and reported outcomes.
Bergamot Polyphenols has been researched for: Cholesterol & Cardiovascular, AMPK Mechanism & Antioxidant, Clinical trials. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 8 out of 9 studies are human trials. Human trials carry more weight in our evidence scoring system.
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