Apigenin
Research reviewed: Up until 03/2026
Apigenin is a dietary supplement with 15 published peer-reviewed studies involving 256 participants, researched for Anxiety & Sleep, Anti-inflammatory & Metabolic, Neuroprotection & Cellular Health and 2 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Anxiety & Sleep
StrongAnti-inflammatory & Metabolic
ModerateNeuroprotection & Cellular Health
ModerateSystematic reviews
WeakClinical trials
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Anxiety & Sleep
To evaluate chamomile extract (apigenin-rich) on generalised anxiety disorder
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate chamomile extract (apigenin-rich) on generalised anxiety disorder
Dose
270 mg/day standardised chamomile extract (1.2% apigenin)
Participants
57 patients with mild-moderate GAD
Duration
8 weeks
Results
Significant reduction in HAM-A total scores vs placebo (p=0.047). Sleep quality and somatic symptoms also improved.
How They Measured It
Hamilton Anxiety Rating Scale (HAM-A), BAI
To assess long-term chamomile extract for prevention of GAD relapse
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To assess long-term chamomile extract for prevention of GAD relapse
Dose
500 mg/day chamomile extract (3% apigenin)
Participants
93 patients with GAD
Duration
26 weeks maintenance
Results
Significantly lower relapse rate in chamomile group (15.2%) vs placebo (25.5%). HAM-A scores remained lower throughout.
How They Measured It
Hamilton Anxiety Rating Scale, relapse rate
To evaluate chamomile tea (apigenin-rich) on sleep quality in elderly
Study Type
Randomised, placebo-controlled
Purpose
To evaluate chamomile tea (apigenin-rich) on sleep quality in elderly
Dose
400 ml chamomile tea twice daily (approx 30 mg apigenin)
Participants
40 elderly adults with poor sleep
Duration
4 weeks
Results
Significant improvement in PSQI total score (p=0.01) and sleep efficiency. Morning cortisol reduced. Daytime fatigue improved.
How They Measured It
PSQI, actigraphy, morning cortisol
Anti-inflammatory & Metabolic
To evaluate apigenin-rich parsley extract on inflammatory markers
Study Type
Randomised, placebo-controlled pilot
Purpose
To evaluate apigenin-rich parsley extract on inflammatory markers
Dose
20 g/day parsley (high apigenin)
Participants
20 healthy adults
Duration
2 weeks
Results
Significant increases in serum apigenin confirming bioavailability. CRP and IL-6 trending toward reduction. Antioxidant enzyme activity increased.
How They Measured It
CRP, IL-6, TNF-alpha, serum apigenin levels
To assess apigenin supplementation on biomarkers of inflammation in overweight adults
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To assess apigenin supplementation on biomarkers of inflammation in overweight adults
Dose
50 mg/day purified apigenin
Participants
30 overweight adults
Duration
4 weeks
Results
Significant reduction in CRP (p=0.04) and IL-8 (p=0.03). NF-kB expression in monocytes reduced.
How They Measured It
CRP, IL-8, TNF-alpha, NF-kB in peripheral blood
Neuroprotection & Cellular Health
To examine apigenin mechanisms for neuroprotection and neurogenesis
Study Type
In vitro and animal study (mechanistic)
Purpose
To examine apigenin mechanisms for neuroprotection and neurogenesis
Dose
Various concentrations
Participants
Cell and animal models
Duration
Various
Results
Apigenin promoted neurogenesis in hippocampal cells and increased BDNF expression. Neuroprotective against oxidative stress.
How They Measured It
Hippocampal cell cultures, neurogenesis markers, BDNF expression
To summarize clinical and preclinical evidence for apigenin in cancer prevention
Study Type
Systematic review
Purpose
To summarize clinical and preclinical evidence for apigenin in cancer prevention
Dose
Various
Participants
Review of preclinical and epidemiological data
Duration
Various
Results
Apigenin demonstrates anti-proliferative, pro-apoptotic activity against multiple cancer cell lines. Dietary flavone intake inversely correlated with cancer risk.
How They Measured It
Apoptosis, cell cycle arrest, angiogenesis inhibition
To evaluate apigenin bioavailability and safety in healthy volunteers
Study Type
Randomised, controlled pilot
Purpose
To evaluate apigenin bioavailability and safety in healthy volunteers
Dose
50-150 mg single dose purified apigenin
Participants
16 healthy volunteers
Duration
Single dose pharmacokinetic study
Results
Dose-dependent increase in plasma apigenin peaking at 2-4 hours. Half-life approximately 18 hours. No adverse effects. Antioxidant capacity increased dose-dependently.
How They Measured It
Plasma apigenin kinetics, safety biomarkers, antioxidant capacity
Systematic reviews
To investigate the effects of Apigenin in potential therapeutic effects of apigenin for colorectal adenocarcinoma: a systematic review and meta-analysis.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Apigenin in potential therapeutic effects of apigenin for colorectal adenocarcinoma: a systematic review and meta-analysis.
Dose
Apigenin (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
rapeutic management of colorectal cancer (CRC) does not yet yield promising long-term results. Therefore, there is a need for further investigation of possible therapeutic options. Various experiments have studied the effects of apigenin on CRC and have shown conflicting results. This systematic review and meta-analysis investigates the currently existing evidence on the effect of apigenin on CRC.
How They Measured It
See study for outcome measures
To investigate the effects of Apigenin in efficacy and safety of natural apigenin treatment for alzheimer's disease: focus on in vivo research advancements.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Apigenin in efficacy and safety of natural apigenin treatment for alzheimer's disease: focus on in vivo research advancements.
Dose
Apigenin (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
Alzheimer's Disease (AD) is the most common dementia in clinics. Despite decades of progress in the study of the pathogenesis of AD, clinical treatment strategies for AD remain lacking. Apigenin, a natural flavonoid compound, is present in a variety of food and Chinese herbs and has been proposed to have a wide range of therapeutic effects on dementia.
How They Measured It
See study for outcome measures
To investigate the effects of Apigenin in antidepressant activity of flavones from traditional chinese medicine: a meta-analysis.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Apigenin in antidepressant activity of flavones from traditional chinese medicine: a meta-analysis.
Dose
Apigenin (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
Flavones, the key active components in Traditional Chinese Medicine (TCM), have demonstrated antidepressant activity. Given the numerous animal studies conducted, a systematic analysis is essential to provide a valuable reference for future research.
How They Measured It
See study for outcome measures
To investigate the effects of Apigenin in apigenin in cancer prevention and therapy: a systematic review and meta-analysis of animal models.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Apigenin in apigenin in cancer prevention and therapy: a systematic review and meta-analysis of animal models.
Dose
Apigenin (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
Apigenin is being increasingly recognized as a cancer chemopreventive agent. We aimed to investigate the anticancer effects of Apigenin in in-vivo studies to know its present research status and how close or how far it is from the clinics.
How They Measured It
See study for outcome measures
To investigate the effects of Apigenin in the effects of apigenin administration on the inhibition of inflammatory responses and oxidative stress in the lung injury models: a systematic review
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Apigenin in the effects of apigenin administration on the inhibition of inflammatory responses and oxidative stress in the lung injury models: a systematic review
Dose
Apigenin (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
s a treatment of different inflammatory disorders and pathological problems associated with oxidative stress (OS). Recent research has focused on apigenin immunomodulatory properties as a potential treatment for different types of lung injuries. This meta-analysis was designed to determine the impact of apigenin treatment on inflammatory markers and OS parameters in animal models of lung injuries.
How They Measured It
See study for outcome measures
Clinical trials
To investigate the effects of Apigenin in efficacy and safety of matricaria chamomilla intervention in managing menopausal symptoms: a triple-blind clinical trial.
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Apigenin in efficacy and safety of matricaria chamomilla intervention in managing menopausal symptoms: a triple-blind clinical trial.
Dose
Apigenin (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
Menopausal symptoms can significantly impact women's quality of life. Herbal interventions like Matricaria chamomilla (chamomile) have been suggested as potential remedies. However, their efficacy and safety remain underexplored.
How They Measured It
See study for outcome measures
To investigate the effects of Apigenin in efficacy of lumateperone in depression associated with bipolar ii disorder: a pooled analysis of late-phase clinical trials.
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Apigenin in efficacy of lumateperone in depression associated with bipolar ii disorder: a pooled analysis of late-phase clinical trials.
Dose
Apigenin (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
Treatment options are limited for depressive episodes in patients with bipolar II disorder. This post hoc analysis evaluated the efficacy of lumateperone in three pooled short-term, Phase 3 studies in patients with a major depressive episode (MDE) associated with bipolar II disorder.
How They Measured It
See study for outcome measures
Frequently Asked Questions
Common questions about Apigenin research
There are currently 15 peer-reviewed studies on Apigenin (Apigenin), involving 256 total participants. Research covers Anxiety & Sleep, Anti-inflammatory & Metabolic, Neuroprotection & Cellular Health and 2 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (8 human studies), and reported outcomes.
Apigenin has been researched for: Anxiety & Sleep, Anti-inflammatory & Metabolic, Neuroprotection & Cellular Health, Systematic reviews, Clinical trials. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 8 out of 15 studies are human trials. Human trials carry more weight in our evidence scoring system.
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