7-Keto-DHEA
Research reviewed: Up until 03/2026
7-Keto-DHEA (3-Acetyl-7-oxo-DHEA) is a dietary supplement with 3 published peer-reviewed studies involving 286 participants, researched for Weight Management, Metabolic Health.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Weight Management
ModerateMetabolic Health
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Weight Management
To evaluate the effect of 7-Keto-DHEA (7-Keto Naturalean) on weight loss in overweight adults
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To evaluate the effect of 7-Keto-DHEA (7-Keto Naturalean) on weight loss in overweight adults
Dose
7-Keto-DHEA 100 mg/day
Participants
Overweight adults
Duration
8 weeks
Results
Patients taking 7-Keto Naturalean lost significantly more weight (2.15 ± 2.38 kg) after 8 weeks than placebo (0.72 ± 2.12 kg), with significant BMI reduction.
How They Measured It
Body weight, BMI
To evaluate the effects of 7-Keto DHEA on resting metabolic rate in overweight adults
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To evaluate the effects of 7-Keto DHEA on resting metabolic rate in overweight adults
Dose
7-Keto-DHEA as part of HUM5007 combination
Participants
Overweight adults
Duration
12 weeks
Results
During 7-Keto treatment period, resting metabolic rate increased significantly by 1.4% compared to placebo.
How They Measured It
Resting metabolic rate via indirect calorimetry
Metabolic Health
To assess the impact of 7-keto-DHEA on body weight across randomized controlled trials
Study Type
Systematic review and meta-analysis
Purpose
To assess the impact of 7-keto-DHEA on body weight across randomized controlled trials
Dose
Various doses (100-250 mg/day)
Participants
Meta-analysis of 4 RCTs with 286 participants
Duration
4-12 weeks across studies
Results
Systematic review identified 4 low-bias RCTs. Half showed significant weight reduction, some showed increased metabolic rate. Mixed but generally positive effects.
How They Measured It
Meta-analysis of RCT data
Frequently Asked Questions
Common questions about 7-Keto-DHEA research
There are currently 4 peer-reviewed studies on 7-Keto-DHEA (3-Acetyl-7-oxo-DHEA), involving 286 total participants. Research covers Metabolism, Weight management, Anti-aging. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (3 human studies), and reported outcomes.
7-Keto-DHEA has been researched for: Metabolism, Weight management, Anti-aging. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 3 out of 4 studies are human trials. Human trials carry more weight in our evidence scoring system.
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